The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,403,398 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on precision imaging approaches for understanding the spatial regulators of the hybrid epithelial/mesenchymal state in head and neck cancer. The project aims to utilize advanced imaging techniques to investigate how the hybrid...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,505 to support the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The goal is to create a small peptide-based fluorescent probe that can specifically stain HNC tumors to assist surgeons in identifying tumors...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $704,206 to Oregon Health & Science University (OHSU) to develop an "organ on-a-chip" model of oral cancer and bone invasion. The goal is to systematically manipulate, characterize, and validate tissue microenvironment variables linked to oral squamous cell carcinoma (OSCC) invasion into bone, elucidate...
This $550,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multimodal imaging diagnostic platform to improve risk assessment of precancerous oral lesions. The key products and services to be delivered under this grant include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging techniques for risk...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $483,360 to the University of California, San Diego (UCSD) to conduct research aimed at identifying new precision therapies for oral cancer. The key focus is to exploit vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry to disrupt immune evasive mechanisms and enhance the activity of anti-PD-1...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $451,000.00 to the University of Chicago to conduct research aimed at deciphering the mechanisms behind patient responses to a novel immunotherapy targeting human papillomavirus (HPV) associated head and neck cancer. The key objectives of this 2-year research project are to leverage patient tumor biopsies, plasma samples,...
This $308,223 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research at Stanford University to define how the gene ACTL6A regulates metabolic reprogramming in head and neck squamous cell carcinoma (HNSCC). The key objectives are to quantify energy production under varying ACTL6A expression levels, explore links between ACTL6A, mitochondrial activity, and cancer stem...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $1,564,226 to Virginia Commonwealth University to investigate the role of FOSL1 super-enhancers in defining the functional properties of cisplatin-enriched cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). The research aims to validate FOSL1 super-enhancers as a target for overcoming...
This $799,270 federal project grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support the development of a novel class of anticancer drugs called 1,3-thioureas for the treatment of oral squamous cell carcinoma (OSCC). The grant recipient, Keraceuticals, Inc., will focus on formulating the lead compound CIDD99 for oral and/or intravenous administration, evaluating its efficacy in mouse...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance understanding of the mechanisms behind radiotherapy resistance in head and neck squamous cell carcinoma (HNSCC). The $320,000 award, effective from July 15, 2025 to July 14, 2027, supports research conducted by Baylor College of Medicine to: Investigate how the KEAP1/NRF2 signaling pathway and the tumor immune...