Project Grant R00DE032094

Award Date 7/1/25
Completion Date 6/30/28
Dollars Obligated $249K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Palo Alto, CA 94304, USA
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The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $249,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Missouri System to develop a novel organopet assay for precision therapy of head and neck cancer.

The key products and services to be delivered under this 3-year grant include:

  1. Establishing a high-throughput automated platform to generate patient-derived tumor organoids (tumoroids) that capture tumor heterogeneity.
  2. Developing a methodology to perform high-throughput screening of tumoroids using 18-F-fluorodeoxyglucose (FDG) PET imaging to correlate with patient tumor FDG uptake.
  3. Examining standard-of-care and emerging treatment response across different head and neck cancer subtypes to determine if DNA methylation patterns correlate with treatment resistance.

The goal is to improve precision treatment and overall survival for head and neck cancer patients by leveraging tumor organoid models and clinical imaging biomarkers.

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