This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $198,750 to the University of Pittsburgh to conduct research aimed at understanding and treating radiation-induced pain and oral mucositis in head and neck cancer patients. The key objectives are to: 1) characterize nociceptive behavior, oral mucositis, and radiation-induced primary afferent nerve sprouting in a mouse...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $808,264 to The Medical University of South Carolina to conduct research on the mechanisms governing the intracellular delivery of small interfering RNAs (siRNAs) using a cell-penetrating peptide carrier called RD3AD. The key objectives are to: (1) uncover the mechanisms of how the RD3AD-siRNA complex...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $273,009 to Virginia Commonwealth University to conduct research on a conserved streptococcal membrane protein affecting manganese utilization. The research aims to determine the crystal structure and characterize the function of this protein, which is hypothesized to be an acyltransferase that plays a role in...
This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop an innovative multimodal imaging diagnostic platform for risk assessment of precancerous oral lesions. The $550,296 award, with a project period from September 2024 to September 2025, will integrate Fourier transform infrared (FTIR) imaging, histological imaging, and spatial transcriptomics techniques,...
The federal Project Grant award R01DE034776 in the amount of $628,965.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award to the Icahn School of Medicine at Mount Sinai aims to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland epithelial cell development and differentiation. Using genetic mouse models and...
The U.S. National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) to the University of California, San Diego (UCSD). The project aims to create advanced artificial mucin substitutes that closely emulate the physiochemical properties and functions of natural salivary mucins. The key objectives are to: (1) craft artificial mucins that mirror the properties of natural salivary...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the role of tuft cells in salivary gland immunity. The $608,632.33 award to The Research Foundation for the State University of New York (RF SUNY) aims to: 1) explore tuft cell distribution and function in salivary gland epithelium, 2) determine tuft cell chemosensory components, and 3) assess the...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Program (CFDA 93.121), provides $115,992 in funding to The Research Foundation for the State University of New York (RF SUNY) to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with optimized secretory function and well-defined architecture. The project aims to create SGOs using engineered...
This $452,681 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the role of the ESCRT (Endosomal Sorting Complexes Required for Transport) machinery in regulating craniofacial development and lipid metabolism in mice. The research aims to determine the tissue-specific contributions of the ESCRT-II component VPS25 in the craniofacial epithelium and...
The federal Project Grant award R01DE033712, totaling $1,564,226 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the role of FOSL1 super-enhancers in determining the functional properties of cisplatin-enriched cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). The project aims to validate FOSL1-SEs as a target for overcoming cisplatin...
This $3,001,833 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to develop novel treatments for radiation-induced salivary gland fibrosis. The primary objectives are to elucidate the molecular mechanisms of altered copper homeostasis in irradiated salivary glands, evaluate the therapeutic potential of salivary gland-specific ATP7A gene silencing, and assess the effects of pharmacologically targeting copper transport to mitigate radiation-induced salivary gland fibrosis and restore saliva secretion. This multi-year project, running from August 2024 through April 2029, is being conducted by the University of Missouri System to advance the understanding and treatment of this debilitating complication of radiation therapy for head and neck cancer.