The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
This federal Project Grant award of $241,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to identify diffusible small molecules that regulate the replication of the bacterium Porphyromonas gingivalis (P. gingivalis). The research aims to establish the identity of growth-promoting cues produced by different strains of P. gingivalis and the bacterium Veillonella parvula that...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $273,009 to Virginia Commonwealth University to characterize a conserved streptococcal membrane protein and its role in manganese utilization and oxidative stress resistance. The goal is to determine the crystal structure and functional characterization of this protein, which is hypothesized to be an acyltransferase...
This Project Grant award of $858,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to explore the mechanisms by which the bacterium Veillonella inhibits the hemolytic activity of the periodontal pathogen Porphyromonas gingivalis. The research aims to: 1) investigate how Veillonella's heme production suppresses P. gingivalis' hemolysis, and 2) determine how P. gingivalis regulates...
This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
This Project Grant award of $310,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, supports a comparative experimental evolution study on gene essentiality in the oral bacteria Streptococcus sanguinis and S. mutans. The research aims to categorize the essential genes in S. mutans, identify and classify suppressor mutations for its evolvable essential genes, and compare the findings...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $656,315 to Temple University to study the impact of cyclic strain on the pathogenesis of oral microbes, particularly Candida albicans and denture-related microbiota. The goal is to mechanistically understand how biomaterial cyclic strain, driven by chewing forces, can influence the virulence and dysbiosis of oral...
This Project Grant award of $226,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define how oral pathogens affect aging-associated immune responses and whether inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-associated immune responses induced by oral pathogens. The research will be conducted by the Medical University of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $762,432 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) in Augusta, GA. The project, titled "Metabolic-Purinergic Fitness in Periodontal Health and Disease", aims to investigate the role of the enzyme CD73 in controlling inflammation and bone loss associated with periodontal disease. The...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $307,000 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Florida to investigate the expression of cellular senescence markers in gingival tissues of individuals with type 2 diabetes and periodontal disease. The project aims to compare senescence markers in healthy and diseased gingival biopsies between individuals with and without type 2 diabetes, and to correlate senescence...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a 5-year, $1,499,159 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Virginia Commonwealth University (VCU) to investigate the composition, biosynthesis, regulation, and pathogenic role of a new class of sulfated glycolipids (SGLs) produced by the oral pathobiont Treponema denticola (TD). The project aims to elucidate the chemical structure and genetic determinants of SGLs, examine how SGL production is regulated in response to biofilm formation, and assess the role of SGLs in TD-induced osteoclastogenesis and alveolar bone loss. Completion of this research will provide new insights into the glycome of TD and its contributions to oral infections and systemic diseases like Alzheimer's and oral cancer. The findings may also open new avenues to investigate SGLs in other pathogenic oral bacteria.