The federal Project Grant award of $1,403,398 was granted on September 2, 2024 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The award supports research aimed at utilizing advanced imaging approaches to develop imaging-based biomarkers related to the hybrid epithelial/mesenchymal state (HEM) and its interactions with the immune system in head and neck squamous cell carcinoma (HNSCC)....
The federal Project Grant award R01DE033797, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to determine if targeting the MARCHF8-autophagy pathway can remodel the tumor microenvironment and activate antitumor immunity in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC). The $642,488 award, with a project period from June 2025 to March 2030,...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $164,322 to the Regents of the University of Michigan to conduct research on intercepting the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. The research aims to investigate how SOX2-driven malignant transformation impacts STING signaling in tumor-resident immune cells, using a preclinical...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $229,440 to the University of Colorado-Denver to investigate the divergent response to radio-immunotherapy in head and neck squamous cell carcinoma (HNSCC) and pancreatic adenocarcinoma (PDAC). The research aims to determine how regulatory T cells mediate the different responses observed between these two cancer types...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,805,385 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oregon Health & Science University (OHSU). The grant aims to define the T cell-based mechanisms underlying oral mucosal immune-related adverse events (irAEs) caused by anti-PD-1 cancer immunotherapy, with the goal of developing strategies to mitigate these side effects. The research will utilize human samples, mouse...
This federal Project Grant award for $480,840, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the role of the Iroquois homeobox 1 (IRX1) gene in regulating oral tissue repair and maintenance. The research aims to determine the expression pattern of IRX1 during embryogenesis and homeostasis, identify the role of IRX1 in oral tissues using lineage tracing models,...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $170,208 to The Washington University to support a 4-year career development plan for R. Alex Harbison, MD. The objective is to prepare Dr. Harbison to become an independent physician-scientist focused on targeting polyamine metabolism to enhance immune responses against head and neck squamous cell carcinoma (HNSC). The...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $503,648 to The University of Iowa to conduct research on identifying transcriptional interplay between skin and oral ectoderm during mandibular patterning. The key objectives are to determine how transcription factors drive the specification of oral/dental or skin fates within the mandibular ectoderm, identify...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at the University of Colorado-Denver to investigate sex-specific differences in the immune microenvironment of head and neck squamous cell carcinoma (HNSCC). The $156,000 award, granted from July 1, 2025 to June 30, 2027, will enable the researchers to use animal models to directly test sex as a biological...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (CFDA 93.121 Oral Diseases and Disorders Research), provides $2,764,816 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, from August 1, 2024 to April 30, 2029. The goal of this research is to better understand how differences in the HPV oncoprotein function contribute to therapy...