Project Grant R01DE034056

Award Date 8/1/24
Completion Date 4/30/29
Dollars Obligated $1.6M
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), is focused on understanding how human papillomavirus (HPV) disrupts DNA damage response signaling in HPV-positive head and neck squamous cell carcinoma (HNSCC). The $249,000 award aims to clarify the mechanisms by which HPV sensitizes cancer cells to the WEE1 inhibitor AZD1775, which induces replication failure and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,743,816 to the Regents of the University of Michigan to study the role of human papillomavirus (HPV) integration structures in driving molecular heterogeneity and tumor progression in HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). The research aims to: 1) Determine the accuracy of using...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $109,548 to investigate the evolution of pro-tumoral myeloid cells during the progression from oral epithelial dysplasia to head and neck squamous cell carcinoma. The goal is to develop pharmacological and genetic strategies to intercept the development of these immunosuppressive myeloid cells, which could lead to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,657,748 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Case Western Reserve University (CWRU) on July 15, 2024. This grant supports research to determine the mechanisms by which the lead molecule OHM1 reactivates the p53 tumor suppressor and p300 proteins, thereby disrupting the HPV E6 protein's ability to inactivate them. The research aims to (1) understand how OHM1 modulates the p53...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $118,763 to the University of Arizona to assess the transformative versus productive infection of human papillomavirus type 16 (HPV16) in oral epithelial tissues. The research aims to characterize the role of the host transcription factor PPARA in regulating HPV16 productivity and tumorigenicity within distinct...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $515,812 to The Johns Hopkins University in Baltimore, Maryland to conduct a prospective observational cohort study. The study aims to: 1) examine the progression to HPV-related oropharynx cancer (HPV-OPC) and how it differs between individuals living with and without HIV; 2) characterize the impact of HIV on oral...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $533,707 to conduct research on how the human papillomavirus (HPV) regulates the Hippo signaling pathway. The goal is to elucidate the mechanism by which the HPV E7 oncoprotein activates the YAP1 oncoprotein by degrading the PTPN14 protein, which normally promotes epithelial cell differentiation. The research...
This federal Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) of the National Institute of Dental and Craniofacial Research (NIDCR) provides $469,830 to Temple University to investigate the potential of health-associated oral bacteria to prevent and enhance immunotherapy treatment for oral squamous cell carcinoma (OSCC). The research aims to assess the ability of the oral bacteria Streptococcus mitis and Haemophilus parainfluenzae to inhibit OSCC...
This federal Project Grant award provides funding for research conducted by Virginia Commonwealth University (VCU) under the National Institute of Dental and Craniofacial Research (NIDCR) Oral Diseases and Disorders Research program (CFDA 93.121). The project's goal is to investigate how the transcription factor FOSL1 and its associated super-enhancers influence the properties of cisplatin-resistant cancer stem cells in head and neck squamous cell carcinoma (HNSCC). The $517,993 award will...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) supports research to investigate viral and host cell factors that contribute to the development of juvenile-onset recurrent respiratory papillomatosis (JORRP), a rare but serious condition caused by low-risk HPV viruses. The $446,728 award, which began on July 5, 2024 and is scheduled to run through June 30, 2029, will enable researchers at Childrens Hospital Medical Center in Cincinnati, Ohio to...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,641,683 in funding to The Trustees of the University of Pennsylvania to conduct research focused on understanding the mechanisms by which human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) become resistant to current radiation and cisplatin therapies.

The goal of the research is to elucidate how differences in HPV oncoprotein function, particularly E6 levels and their impact on mitochondrial biogenesis and antioxidant capacity, contribute to therapy resistance in a subset of HPV+ OPSCC cases. The findings will enable prospective identification of therapy-resistant tumors and define molecular targets to sensitize them to treatment, while also allowing the creation of biomarkers and less toxic therapies for treatment-sensitive cases. The project will run from August 1, 2024 through April 30, 2029.

Generated 4/29/25, 5:03 AM