This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,641,683 in funding to The Trustees of the University of Pennsylvania to conduct research focused on understanding the mechanisms by which human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) become resistant to current radiation and cisplatin therapies. The goal of the research is to elucidate how differences in HPV oncoprotein function, particularly E6 levels and their impact on mitochondrial biogenesis and antioxidant capacity, contribute to therapy resistance in a subset of HPV+ OPSCC cases. The findings will enable prospective identification of therapy-resistant tumors and define molecular targets to sensitize them to treatment, while also allowing the creation of biomarkers and less toxic therapies for treatment-sensitive cases. The project will run from August 1, 2024 through April 30, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $494.7k | 4/18/25 | ||
| Not listed | $573.5k | 7/30/24 | ||
| Not listed | $573.5k | 7/30/24 |