The National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, awarded a $847,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Utah. The 2-year grant, awarded on August 1, 2023, will fund research to develop and evaluate the efficacy of a novel antimicrobial bone scaffold made from zinc-doped fluorapatite for use in craniofacial surgical applications. The research aims to...
This federal Project Grant award of $443,576 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to develop a defined 3D microenvironment that can regulate the self-renewal and differentiation of human induced pluripotent stem cells (hiPSCs) into odontogenic epithelial stem cells (OESCs) and neural crest cells (NCCs). The goal is to co-culture these cell types in a chitosan-alginate...
The federal Project Grant award R01DE033520, totaling $924,616.45, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The goal of this 4-year project is to identify the cellular and molecular mechanisms controlling dental mesenchymal cell differentiation and fate during early tooth development. This research aims to leverage this knowledge to develop potential therapeutics for dentin...
This $606,296 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop new growth models for the craniofacial complex using advanced 3D imaging technology. The research will leverage a large, diverse database of 40,000 CBCT (cone-beam computed tomography) images to create comprehensive growth standards that account for age, sex, race, ethnicity, facial type, and dental...
This federal Project Grant award, under the National Institute of Dental and Craniofacial Research's (NIDCR) Oral Diseases and Disorders Research program (CFDA 93.121), aims to explore repurposing the FDA-approved iron oxide nanoparticle formulation, ferumoxytol, to activate and promote the regenerative capabilities of orofacial mesenchymal stem/progenitor cells (OMSCs) for craniofacial tissue repair and regeneration. The $243,750 award, granted to the Trustees of the University of Pennsylvania,...
This $565,228 federal Project Grant, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies that stimulate endogenous periodontal regeneration. The key products and services to be delivered under this grant include: Identifying specific cell surface markers to isolate and characterize human periodontal ligament stem cells expressing the PRX1 transcription factor...
This $656,315 Project Grant was awarded on September 1, 2024 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The overarching goal is to mechanistically study the effect of biomaterial cyclic strain on the pathogenesis of oral microbes, including the fungal strain Candida albicans and denture-related microbiota. The research aims to understand how chewing actions may fuel the progression of...
This federal Project Grant award of $499,440, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel, multifunctional, and durable dental resin restorations. The grant recipients, including the ADA Forsyth Institute, Inc. and the University of Maryland, Baltimore, are working to create advanced resin-based dental adhesives and composites that resist hydrolysis, enzymolysis, and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will fund a research program to investigate skeletal stem cell plasticity as a central mechanism in craniofacial bone formation and diseases. The lead grantee, the University of Texas Health Science Center at Houston, will receive $2,055,996.00 over an 8-year period beginning on September 20, 2024. The...