Project Grant R01DC021857

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $670K
Federal Grant Program
93.173
Assistance Type
Project Grant
Place of Performance
Indianapolis, IN 46202, USA
Similar Awards
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders" provides $637,500.00 to the Massachusetts Eye and Ear Infirmary to conduct research on understanding human cochlear micromechanics. The goal is to study the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies organ of Corti motion...
This five-year, $734,582 Project Grant from the National Institute on Deafness and Other Communication Disorders will fund research at Lehigh University to investigate the developmental determination of central auditory physiology by the inner ear. The grant is part of the Research Related to Deafness and Communication Disorders program. Specifically, the university will develop a model of repatterned frequency representation in the chick inner ear by overexpressing the bone morphogenetic...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA Program 93.173 "Research Related to Deafness and Communication Disorders", provides $690,773 to The Leland Stanford Junior University (Stanford University) from December 15, 2024 to November 30, 2029. The project aims to understand how the hair bundle structure and stimulation in the inner ear shape the receptor current that generates the electrical...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $1,277,317 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to the Medical University of South Carolina (MUSC). The award period runs from August 15, 2024 through May 31, 2029. The grant supports research to investigate the relationship between autism spectrum disorders (ASDs) and auditory system deficits, with a focus on the role of neuronal and immune...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA 93.173 Research Related to Deafness and Communication Disorders program, will support research on age-related auditory nerve degeneration and potential treatments. The $102,324 award, effective September 1, 2025 through August 31, 2027, will be administered by the Medical University of South Carolina. The key objectives are to: 1) Define age-dependent changes in Dectin-1...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $581,105 to Creighton University to develop natural-based therapies for treating hearing loss caused by aminoglycoside antibiotics. The key focus is on designing, synthesizing, and testing piperlongumine derivatives that can better target the TRPV1 channel to protect hair cells and synapses...
This Project Grant award of $194,400.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the CFDA 93.173 Research Related to Deafness and Communication Disorders program supports research into the mechanisms underlying a Meniere's disease subtype known as MDHP. The key products and services to be delivered under this award include: Establishing the phenotypic and genotypic link between the MDHP subtype of Meniere's disease and X-linked hypophosphatemia...
This federal Project Grant award of $448,687, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to investigate the role of calcium regulation in outer hair cells (OHCs) and their sensitivity to cochlear injury. The research aims to enhance understanding of the mechanisms that protect OHCs, which act as sentinels of cochlear injury, from damage due...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $262,001 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, which runs from September 30, 2024 to April 30, 2026, will fund research to investigate the underlying causes of "hidden" age-related hearing loss, which affects sound...

This Project Grant award of $670,318, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 - Research Related to Deafness and Communication Disorders, will fund research to investigate the biological functions of the CHD7 gene and its role in the inner ear development pathology of CHARGE syndrome.

The key objectives are to: 1) Establish human embryonic stem cell lines with specific CHD7 mutations to study their impact on gene/protein expression and chromatin regulation in inner ear organoids, 2) Determine if downregulation of known deafness genes in CHD7-deficient hair cells contributes to hearing loss in CHARGE syndrome, and 3) Elucidate the transcriptional regulatory mechanisms of CHD7 during inner ear development. Additionally, a $106,406 sub-award to the University of Kentucky Research Foundation will support characterizing the functional and structural properties of sensory hair cells derived from the human pluripotent stem cell organoids.

The research, led by the Trustees of Indiana University, aims to increase understanding of CHD7 biology and provide insights into the etiology of inner ear abnormalities in CHARGE syndrome. The multi-year project runs from December 2024 to November 2029.

Generated 8/5/25, 3:51 AM