This Project Grant award was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to The Medical University of South Carolina (MUSC). The $145,642 award, which began on September 1, 2024 and is scheduled to conclude on May 31, 2025, will support research investigating mitochondrial dysfunction as a driver of stria vascularis degeneration and inflammation in age-related...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $1,277,317 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to the Medical University of South Carolina (MUSC). The award period runs from August 15, 2024 through May 31, 2029. The grant supports research to investigate the relationship between autism spectrum disorders (ASDs) and auditory system deficits, with a focus on the role of neuronal and immune...
This federal Project Grant award of $477,660 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research to investigate age-related brain differences that affect speech recognition in older adults. The primary objectives are to characterize how quickly older adults accumulate sensory evidence and how much evidence they require to make speech recognition decisions, and to link these perceptual...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $415,743 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to Oregon Health & Science University (OHSU). The 5-year grant, effective February 1, 2025, will support research to investigate the role of macrophages in the development, homeostasis, and repair of the tympanic membrane (eardrum). The project aims to characterize the origin and function of...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders" provides $637,500.00 to the Massachusetts Eye and Ear Infirmary to conduct research on understanding human cochlear micromechanics. The goal is to study the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies organ of Corti motion...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $262,001 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, which runs from September 30, 2024 to April 30, 2026, will fund research to investigate the underlying causes of "hidden" age-related hearing loss, which affects sound...
This federal Project Grant award for $146,206, awarded on December 15, 2024 by the National Institute on Deafness and Other Communication Disorders (NIDCD), supports research on the "Cortical and Subcortical Dynamics in the Central Auditory System Across Learning and Overtraining". The project, which runs through August 15, 2027, aims to investigate how the auditory cortex interacts with subcortical regions like the medial geniculate body and inferior colliculus to support auditory...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $115,707 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to the Rector & Visitors of the University of Virginia (UVA). The grant supports research investigating how phospholipid homeostasis regulates hair cell function and health, using mouse models deficient in the phospholipid flippase ATP8B1 or its cofactor TMEM30B. The research aims to uncover the...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $131,555 to Oregon Health & Science University (OHSU) for a 2-year period from July 1, 2025 to June 30, 2027. The project aims to investigate how noise-induced hearing loss (NIHL) affects the central auditory processing of natural sound categories in the auditory cortex. Key...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA 93.173 Research Related to Deafness and Communication Disorders program, will support research on age-related auditory nerve degeneration and potential treatments. The $102,324 award, effective September 1, 2025 through August 31, 2027, will be administered by the Medical University of South Carolina.
The key objectives are to: 1) Define age-dependent changes in Dectin-1 expressing macrophages/microglia associated with auditory nerve demyelination in mice and human donors, and 2) Evaluate if reducing Dectin-1 expression can prevent auditory nerve myelin degeneration, microglia activation, and auditory function loss in a mouse model. This research aims to advance the understanding of macrophage/microglia contributions to age-related auditory nerve pathology and identify potential biomarkers and therapeutic targets.