Project Grant R01DA066684
- Federal Grant Award Summary The National Institute on Drug Abuse awarded a $206,180 Project Grant to The Regents of the University of California, San Francisco, effective September 1, 2025, through August 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). The ACCOMPLISH (Applied Coaching of Computational Learners in Substance Use and HIV) Mentoring Program delivers research services focused on investigating the intersection of methamphetamine use, HIV infection, and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, San Diego a $4.95 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) for the Brain-Focused Research on Antiretrovirals and Methamphetamine (BRAIN-FRAME) initiative. The award, effective May 15, 2026, through March 31, 2031, supports a multidisciplinary research program investigating how long-acting injectable antiretroviral therapy (LAI-ART) and...
- Grant Award Summary Drexel University received a $143,110 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective August 1, 2026 through July 31, 2028. The project, titled "Corticostriatal Glial and Peripheral Immune Mechanisms of Polysubstance Use and Associated Comorbidities," investigates the intersection of human immunodeficiency virus (HIV) infection and polysubstance use—specifically cocaine and...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Miami's Office of Research Administration—School of Medicine a $164,190 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective August 19, 2026, with completion targeted for March 31, 2030. This research initiative investigates the mechanistic underpinnings of cognitive impairment resulting from concurrent HIV infection and methamphetamine (METH) use,...
- This $2.05 million Project Grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on May 15, 2026, supports a five-year research initiative at Emory University examining the intersection of substance use and HIV treatment efficacy during pregnancy. The research will elucidate mechanisms by which cocaine and cannabis use antagonize antiretroviral therapy (ART) transport and metabolism at the maternal-fetal interface,...
- The National Institute of Neurological Disorders and Stroke awarded the University of Colorado a Project Grant totaling $184,506 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with an ultimate completion date of July 31, 2027, supports research investigating the dual roles of amyloid beta (AB) in central nervous system neuropathogenesis associated with HIV-Associated Neurocognitive Disorder...
- Grant Award Summary The University of California, San Diego received a $150,104 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct secondary data analysis investigating developmental brain connectomes and substance use in adolescence. The award, effective January 30, 2026 through August 14, 2027, supports research examining how nicotine and tobacco product use impact structural and functional brain networks...
- Summary The National Institute on Drug Abuse (NIDA) awarded $6.94 million to The Research Foundation For The State University Of New York, doing business as SUNY Downstate Health Sciences University, under the Drug Use and Addiction Research Programs (CFDA 93.279) Project Grant mechanism. The award, effective September 30, 2025, through June 30, 2029, funds a longitudinal research study examining neighborhood conditions, neural circuits, and substance use behaviors across the early life...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a $865,823 Project Grant on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate immune mechanisms impacting the blood-brain barrier (BBB) in people who inject drugs (PWID) with and without HIV. The research will be conducted in Baltimore, Maryland, with an ultimate completion date of March 31, 2031. The project leverages a multidisciplinary...
- Federal Project Grant Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $1,387,755 Project Grant effective March 1, 2026, through December 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mitochondrial oxidative phosphorylation dysfunction in the context of HIV-associated neurocognitive disorders (HAND) and opioid use disorder (OUD). The grant supports research to develop and test NAD+ (nicotinamide adenine dinucleotide) as a...
FOSTERING NEW LESSONS FROM COLLABORATIONS TO STUDY STIMULANTS, HIV, AND BRAIN AGING IN EXISTING COHORTS WITH KEY DATA (FLASHBACK) The National Institute on Drug Abuse (NIDA) awarded a $1,055,312 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to The Regents of the University of California, San Francisco, effective August 1, 2026 through May 31, 2031. This research project will assess the impact of stimulant and polysubstance use on brain age gap (BAG)—a machine learning-derived imaging metric measuring the difference between chronological age and predicted brain age from MRI phenotypes—and examine how these factors simultaneously influence cognitive function in people living with HIV (PWH). The study will leverage existing brain MRI data, proteomics data, and cognitive assessments from two NIH-funded cohorts: "Cocaine Use, Viral Suppression and Precursors of Stroke in HIV Infection" (CUPS) and related studies. The research will analyze the convergent effects of stimulant and polysubstance use, cardiovascular disease-related proteomic profiles, and brain aging on cognitive impairment risk in PWH. By identifying modifiable drivers of brain age gap and their interrelationships, the FLASHBACK project aims to generate precision intervention strategies to preserve brain health and detect individuals at risk for cognitive decline during pre-symptomatic stages. This work addresses critical gaps in understanding how substance use and HIV interact to accelerate neurological aging alongside cardiovascular dysfunction and inflammatory processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 7/17/26 |