Project Grant K24DA064477
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will provide $2,331,737 to the University of California, San Francisco (UCSF) to conduct research on the impact of methamphetamine use on immune dysfunction and HIV reservoir transcription among people with HIV receiving antiretroviral therapy. The research will utilize in vivo imaging and post-mortem studies to examine how methamphetamine use...
- This federal Project Grant, awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $804,728 to the Regents of the University of California at Riverside to investigate the role of the cysteinyl leukotriene-cysteinyl leukotriene receptor 1 (CYSLT-CYSLTR1) axis in promoting HIV-1 persistence and brain injury in individuals living with HIV who use methamphetamine. The 5-year project, starting June 1, 2025, aims to determine...
- This Project Grant award of $198,854 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports a study to measure social isolation, loneliness, and stigma experienced by older adults living with HIV who use methamphetamine. The research will characterize trajectories of social isolation and loneliness over 12 months, and explore patient perspectives on how...
- The University of California, San Diego (UCSD) was awarded a $2,223,769 Project Grant from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), with an award date of April 15, 2025 and an ultimate completion date of January 31, 2030. The grant will fund a comprehensive investigation to uncover the mechanistic intersection through which HIV and opioids heighten inflammation, with the goal of offering insights for targeted interventions...
- The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $687,416 Project Grant to the J. David Gladstone Institutes in San Francisco, California. The grant is for a research project titled "Targeted Small Molecule Recruitment to Suppress the HIV Transcriptionally Active Reservoir" and runs from May 15, 2025 to March 31, 2030. The key objectives of this research project are to develop therapeutically effective...
- This $1,144,344 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to develop a novel gene therapy approach to eliminate the HIV/SIV reservoir in the central nervous system of methamphetamine-exposed rhesus macaques on antiretroviral therapy. The research will use a specialized AAV vector (R2MAC) capable of penetrating the blood-brain barrier to deliver multiplex CRISPR/Cas editors targeting the viral...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $3,939,754 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Northern California Institute for Research and Education, Inc. (NCIRE) for the "Stimulant and Polysubstance Use, Inflammation and Sex Effects on Myocardial Disease in HIV (SPISE)" research program. The goal of this 5-year project, beginning July 15, 2025, is to investigate the role of stimulant...
- The University of California, San Diego (UCSD) was awarded a $4,874,620 Cooperative Agreement from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding will support a binational cohort study to prospectively examine the intersection of substance use, HIV, and associated comorbidities among people who inject drugs in the San Diego region. Key objectives include characterizing trends and predictors of established and emerging...
- This federal Project Grant award of $272,395.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to develop methods for targeting the G9A and GLP enzymes, which are involved in the development of addictive behaviors to stimulants and opioids. The research aims to better understand the molecular functions of G9A and GLP in the addiction process and explore therapeutic approaches that do not rely on catalytic site...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $608,652 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Scripps Research Institute. The purpose of this 5-year award, with a start date of September 1, 2025, is to conduct data mining and functional validation of the Systematic Characterization of Retroviral Conditions for Health (SCORCH) datasets. The research aims to elucidate the key pathogenic...
The University of California, San Francisco (UCSF) was awarded a $206,180 Project Grant from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to investigate the complex intersection of HIV, methamphetamine use, and immune dysfunction. The 5-year grant, awarded on Sep 1, 2025, will support a comprehensive, data-driven research approach to examine how methamphetamine exposure influences HIV reservoir transcription and host immune responses, with the goal of developing computational models to predict the biological consequences of methamphetamine exposure and inform HIV cure strategies. The project will also provide protected time for the principal investigator, Dr. Lee, to expand her mentoring capacity of early-stage data science investigators in the interdisciplinary field of clinical translational HIV and substance use research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/22/25 | ||
| Not listed | $206.2k | 8/21/25 |