Project Grant R01DA066620
- The National Institute on Drug Abuse awarded Duke University $1,744,200 on September 30, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research dissecting and modulating cell type and circuit-specific epigenetic mechanisms of cocaine addiction. The research investigates how cell type-specific molecular changes resulting from repeated cocaine exposure lead to rewiring of brain circuits relevant to cocaine-seeking behavior. Duke will utilize mice repeatedly...
- The National Institute on Drug Abuse awarded the University of North Carolina at Chapel Hill $427,625 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support mapping neural circuit and network contributions to addiction development. The project introduces a novel MRI-compatible cocaine self-administration system integrating calcium imaging with fMRI (termed SORDINO-fMRI) to enable simultaneous recording of neuronal activity in the medial prefrontal cortex and...
- The National Institute on Drug Abuse awarded New York University $411,187 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on trial-to-trial variability in neural circuits and its impact on neural computation and behavioral accuracy. The project integrates theoretical models, statistical methods, and experimental datasets to characterize noise in neural circuits using rodent navigation and nonhuman primate decision-making tasks. The...
- The National Institute on Drug Abuse awarded The Trustees of Princeton University $473,543 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop theoretical frameworks and computational methods for identifying mechanisms of cognitive computations from neural recordings and behavioral data. The award funds three research aims: formulating mathematical theory relating the dimensionality of neural population dynamics to single-cell selectivity patterns...
- The National Institute on Drug Abuse awarded New York University a cooperative agreement valued at $1,240,576 on March 15, 2026, to develop and validate an integrated system for life-long, high-resolution monitoring of mouse colony life to study neurobehavioral mechanisms of social behavior and familial structure. This award falls under the Drug Use and Addiction Research Programs (CFDA 93.279), which supports basic, clinical, translational, and implementation research to advance knowledge and...
- The National Institute on Drug Abuse awarded Northwestern University $722,218 on March 1, 2026, for research on the effects of developmental environment on dopamine circuit structure and function under the Drug Use and Addiction Research Programs (CFDA 93.279). The project runs through December 31, 2030, with place of performance in Chicago, Illinois. The research investigates how early life stress produces long-lasting impacts on dopamine circuit function and development into adulthood, using...
- The National Institute on Drug Abuse awarded Wake Forest University Health Sciences $683,782 under the Drug Use and Addiction Research Programs (CFDA 93.279) on March 1, 2026, to develop computational methods for simultaneous detection of dopamine, serotonin, and norepinephrine neurotransmitters using fast-scan cyclic voltammetry with real-time, sub-second temporal resolution in conscious animal and human subjects. The project extends prior technological innovation by the principal...
- The National Institute on Drug Abuse awarded Yale University $336,250 on April 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a behavioral foundation model that transforms qualitative epidemiological survey responses into quantitative representations of substance use behaviors. The project harmonizes data from the National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III), National Survey on Drug Use and Health (NSDUH), and UK Biobank...
- The National Institute on Drug Abuse awarded the Regents of the University of Michigan $325,904 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop real-time machine learning methods for constructing and perturbing stimulus-shaped neural manifolds. The project deliverables span three aims: developing real-time dimensionality reduction algorithms to construct neural manifolds shaped by external stimulus information; designing probabilistic models for...
- The National Institute on Drug Abuse awarded Cold Spring Harbor Laboratory $460,629 under the Drug Use and Addiction Research Programs (CFDA 93.279) on March 15, 2026, to develop and refine knockout training algorithms that identify one-to-one mappings between neural network model units and individual brain neurons. The research expands machine learning methods that perturb or "knock out" model units in the same manner neurons are inactivated in the brain, training models on behavioral...
The National Institute on Drug Abuse awarded Duke University $446,651 under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2026, for Project Grant R01DA066620. The award funds development, validation, and delivery of a platform for relating natural behavior to neural activity in animal models. The platform will build on foundation models of the brain using machine learning and large-scale neural networks trained across diverse datasets collected from different individuals, brain regions, cell types, behaviors, and experimental contexts. The system will integrate high-resolution whole-body 3D and 2D pose data, vocalizations, and social interactions with cellular and subsecond-resolution neural population activity collected via calcium imaging in freely moving animals. A key innovation is a neural network module invariant to position, order, and cardinality of pose keypoints. Initial model training and benchmarking will use existing datasets in mice and rats, with subsequent validation in songbirds using new data collected during singing in freely interacting birds. The recipient will share all new technology with the scientific community and conduct user testing and feedback integration throughout development to maximize platform usability and accessibility. Work is performed in Durham, North Carolina. The period of performance runs from September 1, 2026, through June 30, 2029. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.7k | 8/28/26 |