This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,742,971.00 to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) Division to investigate the epigenetic regulation of HIV/SIV and cocaine-induced inflammasome activation in the brain and gut, and the potential of cannabinoids to modulate this process. The key objectives are to: 1) Investigate the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,032,192 to Yale University to conduct research on the cell-type specific epigenomic effects of cannabis use in people living with HIV. The project aims to dissect the interactions between HIV infection and cannabis use, and identify potential druggable targets through comprehensive profiling of DNA methylation across different cell types. The...
This Project Grant award of $558,668 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs supports research to elucidate the shared and distinct molecular mechanisms underlying the interplay between HIV, substance use disorders (SUD), and neuropsychiatric/neurodegenerative conditions. The award to Massachusetts Institute of Technology (MIT) aims to leverage single-cell transcriptomic, epigenomic, and spatial datasets along with...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769 to the University of California, San Diego (UCSD) to conduct research on the intertwined mechanisms of HIV and opioid use on mitochondrial-mediated inflammasome activation and neurotoxicity. The research aims to elucidate how the convergence of HIV infection and opioid use leads to more severe neurological consequences, including...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $240,108 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the dysregulation of reward-seeking behavior in the comorbid condition of HIV and cocaine use disorder (CUD). The research aims to use circuit-specific optogenetics and chemogenetics in mouse models to understand how HIV infection,...
This Federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $146,922 to The Johns Hopkins University to evaluate the role of endocannabinoid receptors, including CB1, CB2, TRPV2, and PPAR-α, in modulating the inflammatory response of microglia to HIV infection. The goal is to develop a better understanding of how cannabinoids, such as cannabidiol (CBD), can potentially mitigate the chronic...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will provide $234,000.00 to Georgetown University to conduct research on the effect of opioids on HIV transcription and latency. The key objectives are to understand the mechanisms by which opioids such as fentanyl, morphine, and methadone influence HIV proviral transcription in microglia and astrocytes, as well as to longitudinally measure and...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,383,618.00 in funding to The Johns Hopkins University to conduct research on the microglia-mediated adverse effects of cannabis (specifically delta-9-tetrahydrocannabinol or THC) on the maturation of the prefrontal cortex and cognitive function during adolescence. The research aims to elucidate the molecular and cellular mechanisms by which THC...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,398,514 to the San Diego Biomedical Research Institute to conduct research on the molecular effects of cannabinoids on the blood-brain barrier in HIV-infected brains. The goal of this 5-year project is to test the hypothesis that cannabinoids positively impact blood-brain barrier integrity in the HIV-infected brain environment, leading to...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470.00 in funding to Drexel University to develop a new imaging pipeline and analytical approach for examining the spatial architecture of histone dopaminylation in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to connect molecular-level epigenetic changes with behavioral outcomes...