This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $656,121 to The Johns Hopkins University to conduct research on the impact of adolescent cannabis use on cognitive function. The research aims to investigate how THC, the primary psychoactive compound in cannabis, affects the maturation of the prefrontal cortex through microglia-mediated mechanisms, leading to impairments in inhibitory control and response inhibition. Specifically, the project will explore the time course of THC-induced molecular and morphological changes in microglia, how these changes impact prefrontal cortex neuron maturation, and the specific neuronal circuits underlying the observed deficits in cognitive and executive functions. The award period runs from Jan 1, 2025 to Nov 30, 2029.
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