Project Grant R01DA062793
- The National Institute on Drug Abuse awarded The Johns Hopkins University $631,094 on August 1, 2026, for research evaluating the neurocognitive, psychomimetic, and abuse-related effects of emerging psychoactive cannabinoids under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds a five-year project (August 1, 2026 through June 30, 2031) examining vaporized delta-8 tetrahydrocannabinol (D8-THC) and hexahydrocannabinol (HHC)—novel cannabinoids marketed as legal...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $194,271 under Project Grant R21DA064845 on May 1, 2026, for exploratory research on rodent models of cannabis drug discrimination and self-administration to support medication development for cannabis use disorder. The recipient will develop and optimize rodent models using vaporized cannabis extract to establish reliable drug discrimination and self-administration procedures. Aim 1 applies drug discrimination...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $708,190 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 1, 2026, to conduct double-blind, placebo-controlled human laboratory studies examining the pharmacokinetic and pharmacodynamic effects of varying tetrahydrocannabinol (THC) and cannabidiol (CBD) ratios in cannabis edibles. Research Aim 1 will evaluate how different THC:CBD ratios—including 1:0, 1:1, 1:5, 1:10, 1:30, and 0:1—affect THC...
- The National Institute on Drug Abuse awarded Carnegie Mellon University $191,250 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate THC exposure and inhibitory circuit plasticity in the neocortex. The research examines acute and long-term effects of tetrahydrocannabinol (THC), the main psychoactive component of cannabis, on neocortical interneurons expressing the highest levels of cannabinoid receptors in the mammalian brain. The project will...
- The National Institute on Drug Abuse awarded Washington State University $420,750 on July 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the neurobiological substrates of cannabis-seeking behavior through preclinical research models. The funded research combines fiber photometry and wireless recording techniques to examine how dynamic neural activity and dopamine release in corticostriatal circuits—specifically the medial prefrontal cortex and nucleus...
- The National Institute on Drug Abuse awarded the Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $195,804 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds a five-year research project examining how cannabis influences nicotine use among young and emerging adults (ages 18–35) who use electronic nicotine delivery systems. The study integrates human laboratory methods with...
- The National Institute on Drug Abuse awarded Washington State University $639,915 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to interrogate the mechanistic underpinnings of cognitive inflexibility in cannabis-exposed offspring. The research employs a novel, translationally relevant model of cannabis vapor exposure in pregnant rat dams, using custom-designed equipment to deliver discrete puffs of vaporized, plant-derived cannabis extracts in a...
- Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $385,638 to The Regents of the University of Colorado (University of Colorado-Denver) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2025, with a completion date of August 31, 2028. This research award funds a three-year neurobehavioral investigation titled "Cannabinoid Tolerance Across Neurodevelopment: Disruption of Value-Driven Behavior and Prevention Through...
- The National Institute on Drug Abuse awarded The Leland Stanford Junior University $160,840 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate TRPV1-mediated vascular and neuronal dysregulation induced by natural and synthetic cannabinoids. The research examines differential impacts of natural cannabinoids (cannabidiol, delta-9-tetrahydrocannabinol) and synthetic cannabinoids (cannabinol, hexahydrocannabinol) on vascular and neuronal function, with...
- The National Institute on Drug Abuse awarded Auburn University $173,128 on November 29, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support training and experimental research on the neurobiological mechanisms underlying cannabis use disorder. The project, titled "Experimental Manipulation of the Emotional Salience of Cannabis Use-Related Information," will provide training in transcranial magnetic stimulation (TMS) methodology, magnetic resonance imaging...
The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University $718,124 on September 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate chronic cannabinoid vapor exposure effects on the brain and behavior. The research examines whether repeated exposure to vaporized delta-9-tetrahydrocannabinol (THC) causes lasting behavioral and neurological alterations in adult male and female rats, including disrupted neural connectivity, white matter damage, and neuroinflammation. The project tests the hypothesis that chronic THC vapor increases neuroinflammation, triggering inflammatory-driven white matter degradation and persistent disruptions in neural connectivity and associated behavioral deficits. Work will assess long-term effects on executive function and anxiety-like behavior; white matter integrity and myelin plasticity; and changes to the neuro-immune landscape by measuring inflammatory biomarkers, immune cell population signatures, and microglial activity. Performance occurs in Baltimore, Maryland, with a period of performance from September 15, 2026 through July 31, 2031. This is a Project Grant, a standard assistance type under the NIDA program, which supports basic, clinical, translational, and implementation research in substance use to develop prevention, diagnosis, and treatment approaches for drug use, misuse, addiction, and related health outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $718.1k | 9/3/26 |