The National Institute on Drug Abuse (NIDA) awarded Magee-Womens Research Institute and Foundation a $3,092,159 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to conduct a multimodal analysis of gestational health and placental injury in opioid-affected pregnancies. The goal is to investigate the direct impact of illicit and prescription opioids on placental development, differentiation, and function, focusing on the critical syncytiotrophoblast and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is intended to investigate whether a pharmacist-integrated model of opioid use disorder (OUD) treatment can increase naloxone co-prescribing in primary care. The $193,336 award to Trustees of Dartmouth College will fund a research project with three aims: (1) describing federal, state, and clinic-level policies and OUD interventions impacting...
The National Institutes of Health (NIH) awarded Boston Medical Center Corporation a $2,573,346 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The 3-year grant, which commenced on September 1, 2023, will fund a prospective cohort study comparing 100 opioid-exposed pregnancies to 50 non-exposed controls. The study aims to: Compare serial microRNA (miRNA) signatures in opioid-exposed and control pregnancies using maternal plasma and placental tissue samples. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a research project entitled "Optimizing Developmental Outcomes in Early Childhood After Neonatal Opioid Withdrawal Syndrome." The $180,059 award, effective August 1, 2024, will fund a 5-year longitudinal study to assess the independent and moderating effects of positive childhood experiences (PCEs) and adverse childhood experiences...
The National Institute on Drug Abuse (NIDA) awarded The Washington University a 3-year, $2,337,729 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to study the impact of prenatal opioid exposure on placental and fetal brain development. The project, titled "The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta" (OPIOID BPP), aims to define the longitudinal effects of prenatal opioid exposure on...
This $6,439,263 federal Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Abuse and Addiction Research Programs) aims to determine the impact of maternal substance use on maternal immune activation, placental function, and offspring neurobehavioral development. The project will leverage the Healthy Brain and Child Development (HBCD) study to perform maternal immune profiling, placental and cord blood analysis, and novel neuroinflammation imaging on 400 pregnancies...
This Project Grant award of $3,011,183 from the National Institute on Drug Abuse (NIDA), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate the effects of maternal opioid use disorder (OUD) on the placenta-brain axis and associated neurocognitive outcomes in offspring. The University of Kentucky Research Foundation, the prime awardee, will utilize a systems biology approach to integrate phenotypic, functional, and genomic data from the...
The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $1,088,999 Project Grant to The Trustees of Columbia University in the City of New York, effective August 15, 2024 through May 31, 2029. The objective of this project is to develop efficient statistical estimators for analyzing data fusion of multi-study, multi-outcome clinical trials for treating opioid use disorder. The project aims to: 1) create parametric and...
The National Institute on Drug Abuse (NIDA) awarded a $707,647 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to Weill Medical College of Cornell University to conduct research on universal hepatitis C virus (HCV) screening during pregnancy. The project aims to: 1) determine if revised HCV testing guidelines led to increased testing rates among pregnant women compared to non-pregnant women; 2) assess if the guidelines increased postpartum HCV linkage to care, treatment,...
The National Institute on Drug Abuse (NIDA) awarded a $1,464,467 Project Grant under CFDA 93.279 - Drug Use and Addiction Research Programs to Baystate Medical Center, Inc. to conduct a "Type I Hybrid Effectiveness-Implementation Trial of 'Mothering from the Inside Out' (MIO)". The MIO intervention is an attachment-based parenting program targeting mothers with substance use disorders. The grant will fund a randomized effectiveness trial to evaluate MIO's impact on parental...
The National Institute on Drug Abuse (NIDA) awarded a Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) totaling $1,499,606.00 to the Dartmouth-Hitchcock Clinic, doing business as Dartmouth-Hitchcock Obligated Group, with a project period from September 30, 2024 to July 31, 2029.
The goal of this project is to characterize health outcomes from birth to 5 years of age in children born to individuals with opioid use disorder, identify disparities across populations, and ascertain protective health system factors. The research team will conduct a population-level analysis of 1.7 million racially and ethnically diverse maternal-infant dyads insured by Medicaid, including over 1.3 million Hispanic and/or Black women, 250,000 rural-residing women, 26,000 women with disabilities, and 12,000 with opioid use disorder. The project will examine variation in the diagnosis of neonatal opioid withdrawal syndrome, determine the incidence of neurodevelopmental and chronic conditions, and identify protective health system factors.
Dartmouth-Hitchcock Clinic is collaborating with the University of Texas Health Science Center at Houston and Dartmouth College on this project through sub-award arrangements to leverage their expertise in data analysis, project methodology, and stakeholder engagement.