Project Grant R01DA061865
- Federal Grant Award Summary The National Institute on Drug Abuse awarded a $1.62 million Project Grant to the University of Massachusetts Medical School under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of striatal molecular rhythms in sleep disruption and opioid use disorder (OUD). The award, effective August 1, 2025, through April 30, 2030, will deliver fundamental research examining how molecular rhythm disruptions in specific brain cell types of the...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Children's Hospital of Philadelphia Research Institute a $534,000 Project Grant effective September 1, 2025, through May 31, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative investigates the lifespan effects of prenatal and perinatal opioid exposure on the brain's metabolic-epigenetic axis. The project addresses a critical gap in neuroprotective treatment...
- Federal Grant Award Summary The University of Washington received a $139,812 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective August 6, 2026 through March 15, 2029. This award supports basic neuroscience research investigating the mechanisms by which kappa opioid receptor (KOR) activation regulates serotonin and dopamine dynamics during stress-induced aversion. The research addresses a critical public...
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $549,436 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 16, 2025, with a completion date of January 31, 2027. This two-year research initiative investigates the neural mechanisms underlying fentanyl-linked context memories with the objective of developing novel therapeutic interventions to...
- Federal Project Grant Award Summary Carnegie Mellon University received a $935,287 Project Grant award from the National Institute on Drug Abuse (NIDA), administered under the Drug Use and Addiction Research Programs (CFDA 93.279), effective August 1, 2025, through April 30, 2030. The award funds research investigating the genetic and molecular connections between substance use disorders—particularly opioid use disorder—and circadian sleep regulation. The project employs high-throughput...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $1.19M Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a three-year mechanistic research study on the bidirectional relationships between cannabis use, sleep, and the hypothalamic-pituitary-adrenal (HPA) axis. The research addresses the significant public health gap regarding cannabis use disorder (CUD),...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a $577,531 Project Grant on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a multiomic analysis of brainstem respiratory control regions in fentanyl overdose decedents. The research will generate the first single-nucleus paired RNA sequencing and single-nucleus assay for transposase-accessible chromatin sequencing (multiome) data from the...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $352,540 to The Children's Hospital of Philadelphia Research Institute under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2025, for a five-year project concluding July 31, 2030. This project grant funds research to develop and evaluate an adolescent-centered anticipatory guidance intervention designed to prevent postoperative opioid misuse (POM) among the 1.4 million U.S....
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 15, 2025, with completion scheduled for August 31, 2027. This R21 exploratory grant funds fundamental neuroscience research investigating the neurobehavioral consequences of fentanyl overdose and their relationship to relapse risk in individuals with opioid use...
- Federal Project Grant Award Summary Seattle Children's Research Institute received a $762,550 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded on August 15, 2025, with a completion date of April 30, 2030. This research initiative will deliver longitudinal scientific research examining the causal relationships between sleep deficiency and...
Seattle Children's Research Institute received a $574,954 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective May 1, 2026, through February 28, 2031. This award supports fundamental neuroscience research aimed at elucidating homeostatic mechanisms of the locus coeruleus (LC), the brain's principal norepinephrine source, to understand how these mechanisms contribute to opioid-induced sleep disturbances. The research directly addresses a critical public health need, as sleep dysfunction in opioid use disorder has been shown to facilitate opioid dependence and relapse, particularly during withdrawal periods when overdose risk is heightened. The project deliverables encompass multi-level investigations of opioid-induced homeostatic changes in the LC-norepinephrine (NE) system, spanning circuit-level, synaptic-level, and transcriptional-level analyses. By characterizing how LC hyperactivity disrupts sleep during opioid withdrawal, this research is expected to identify new molecular targets and intervention points for mitigating withdrawal symptoms and associated sleep disturbances. Findings will contribute to the broader understanding of neurobiology underlying opioid use disorder and advance treatment approaches for addressing the ongoing opioid epidemic.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $575.0k | 5/7/26 |