Project Grant R01DA061811
- Award Summary Brigham and Women's Hospital, Inc. received a $794,542 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded June 15, 2026, with a completion date of March 31, 2031. The grant funds a comprehensive research initiative to assess the risk of Fetal Fentanyl Syndrome (FFS)—a pattern of structural abnormalities potentially caused by maternal fentanyl abuse during pregnancy—and to evaluate the broader...
- The University of Mississippi Medical Center (UMMC) was awarded a $1,509,492 project grant from the National Institute on Drug Abuse (NIDA) under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to investigate the effects of fentanyl use during pregnancy on maternal health, placental function, and offspring development. Over the 3-year project period from August 1, 2023 to July 31, 2026, UMMC will conduct comprehensive assessments on pregnant female rats self-administering...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $432,754 Project Grant to The University of Kentucky Research Foundation for the period June 1, 2026 through May 31, 2028 under the Drug Use and Addiction Research Programs (CFDA 93.279). This research project investigates dual enkephalinase inhibitor-based therapeutic interventions to mitigate nociceptive sensitization and withdrawal symptoms in neonates and offspring exposed to fentanyl in utero. The research...
- This Project Grant award, totaling $400,294, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding supports research to investigate the neurobiological mechanisms by which adverse childhood experiences (ACEs) and chronic stress alter the rewarding effects of the synthetic opioid fentanyl. Specifically, the project aims to determine the therapeutic potential of the serotonin 2A receptor (5-HT2AR) in modulating...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Nebraska Medical Center (UNMC) a Project Grant totaling $438,950 under the Drug Use and Addiction Research Programs (CFDA 93.279) for research on mechanisms underlying polysubstance use following social defeat in HIV-positive adolescents. The award, dated May 1, 2026, with completion targeted for April 30, 2028, supports basic and translational research investigating how psychosocial...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Nebraska Medical Center a $1.43M Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through May 31, 2030. The research project investigates the synergistic effects of nicotine and antiretroviral therapy (ART) on placental development in pregnant women living with HIV-1. This study addresses a critical knowledge gap regarding how combined...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Tufts University School of Medicine a Project Grant of $386,500 under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on the neurobehavioral mechanisms linking fentanyl overdose to anhedonia and relapse risk. The award, issued September 15, 2025, with a completion date of August 31, 2027, will fund research utilizing an established fentanyl overdose model in male and female rats...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Washington University a Project Grant of $116,865 on August 3, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of locus coeruleus mu opioid receptors in fentanyl drug seeking. The research addresses the escalating opioid epidemic by examining how mu opioid receptors (MOR) in the locus coeruleus—the brain region originating the central noradrenergic system—modulate...
- Federal Grant Award Summary The University of Nebraska Medical Center (UNMC) received a $544,256 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on microglial ferritinophagy in HIV and cocaine-mediated neuroinflammation. The award, effective May 15, 2026 through February 28, 2031, funds investigative research aimed at understanding how selective autophagic turnover of ferritin (ferritinophagy) and...
The University of Nebraska Medical Center (UNMC) received a $503,486 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning July 15, 2026 and completing April 30, 2031. This research initiative investigates a newly identified fetal fentanyl syndrome (FFS) characterized by developmental abnormalities in newborns exposed in utero to non-prescription fentanyl. The project examines whether fentanyl inhibits post-lanosterol cholesterol biosynthesis—particularly in fetuses with DHCR7 (7-dehydrocholesterol reductase) pathogenic variants—thereby replicating the phenotypic features of Smith-Lemli-Opitz Syndrome through an acquired rather than genetic mechanism. The research deliverables encompass three primary investigative aims: (1) examination of the mu-opioid receptor's role in fentanyl-mediated sterol inhibition using in vitro methods; (2) biochemical and morphological outcome analysis in pregnant mouse models with and without DHCR7 pathogenic variants; and (3) analysis of fentanyl exposure effects on maternal blood sterol profiles in pregnant women. This translational research addresses a critical gap in understanding intrauterine drug exposure vulnerabilities and contributes to NIDA's broader portfolio supporting prevention, diagnosis, and treatment research for drug use, misuse, and addiction-related health outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $503.5k | 7/15/26 |