This Project Grant award of $135,906 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the impact of perinatal fentanyl exposure on the development of the mesolimbic dopamine pathway and associated behavioral outcomes. The research aims to use differential gene expression, morphological analysis, and fiber photometric recording to investigate how perinatal fentanyl exposure affects the structure and function...
This Project Grant award, valued at $192,500.00 and provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to understand the effects of gestational fentanyl exposure on the offspring of pregnant women. The research aims to measure the impact on offspring morbidity, mortality, developmental milestones, external morphology, blood cholesterol, brain morphology and neurochemistry, and neonatal opioid withdrawal. The...
The National Institutes of Health (NIH) awarded Boston Medical Center Corporation a $2,573,346 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The 3-year grant, which commenced on September 1, 2023, will fund a prospective cohort study comparing 100 opioid-exposed pregnancies to 50 non-exposed controls. The study aims to: Compare serial microRNA (miRNA) signatures in opioid-exposed and control pregnancies using maternal plasma and placental tissue samples. The...
The National Institute on Drug Abuse (NIDA) awarded Magee-Womens Research Institute and Foundation a $3,092,159 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to conduct a multimodal analysis of gestational health and placental injury in opioid-affected pregnancies. The goal is to investigate the direct impact of illicit and prescription opioids on placental development, differentiation, and function, focusing on the critical syncytiotrophoblast and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a research study focused on understanding the impact of the opioid fentanyl on individuals with HIV. The total funding amount is $587,188, with the award period running from July 15, 2025 to March 31, 2030. The key products and services to be delivered under this grant include: A multi-omics approach and complementary in vivo and ex vivo studies to...
The National Institute on Drug Abuse (NIDA) awarded The Washington University a 3-year, $2,337,729 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to study the impact of prenatal opioid exposure on placental and fetal brain development. The project, titled "The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta" (OPIOID BPP), aims to define the longitudinal effects of prenatal opioid exposure on...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the impact of fentanyl consumption on noradrenergic plasticity in the basolateral amygdala. The $184,706 award to the University of North Carolina at Chapel Hill will fund a 5-year study to investigate how patterns of fentanyl consumption and withdrawal alter brainstem noradrenergic neurons and disrupt norepinephrine signaling in the...
The University of Mississippi School of Pharmacy (UMSOP) received a $3,230,000 Project Grant from the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Congressional Directives (CFDA 93.493) federal grant program. This 1-year award, effective from September 30, 2024 to September 29, 2025, supports a comprehensive initiative to expand naloxone and fentanyl test strip (FTS) awareness and access among college and high school students in northern Mississippi. The project...
This Project Grant award of $3,011,183 from the National Institute on Drug Abuse (NIDA), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate the effects of maternal opioid use disorder (OUD) on the placenta-brain axis and associated neurocognitive outcomes in offspring. The University of Kentucky Research Foundation, the prime awardee, will utilize a systems biology approach to integrate phenotypic, functional, and genomic data from the...
This $6,439,263 federal Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Abuse and Addiction Research Programs) aims to determine the impact of maternal substance use on maternal immune activation, placental function, and offspring neurobehavioral development. The project will leverage the Healthy Brain and Child Development (HBCD) study to perform maternal immune profiling, placental and cord blood analysis, and novel neuroinflammation imaging on 400 pregnancies...