This federal Project Grant award, valued at $825,383, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the role of molecular rhythms in the striatum on sleep and opioid use disorder (OUD). Key objectives include: Using single nuclei RNA-sequencing and time-of-death analyses to create a cell type-specific map of molecular rhythms in subregions of the human striatum. Comparing...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $458,452 to the University of Utah to conduct research on the interrelationship between sleep, circadian rhythms, and substance use disorders. The key objectives are to: 1) determine the mechanisms of psychostimulant-induced sleep changes, 2) screen Drosophila orthologs of human brain-enriched transcripts for their role in...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support a $346,911 cross-species research study to identify early life environmental and genetic risk factors for substance use disorders (SUDs). The key objectives are to: 1) determine how early life environment influences neurocognitive development and its relationship to adult impulsivity behaviors; 2) identify genomic networks associated...
The National Institute on Drug Abuse (NIDA) awarded a $249,860 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to President and Fellows of Harvard College, doing business as Harvard Medical School, to conduct research on the relationship between REM sleep disruption, substance use disorders, and affective disorders. The research aims to delineate the function and brain circuitry involving a specialized subtype of dual serotonergic-glutamatergic neuron that could link sleep...
This federal Project Grant award of $357,613 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to identify novel rare and common genetic variants associated with substance use disorders (SUDs) and enhance disease prediction through a whole-genome multi-ancestry polygenic risk score framework. The research, conducted by Yale University, aims to leverage large-scale whole-genome sequencing datasets to address...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to study the neurogenetic mechanisms underlying nicotine and cannabis addiction. The $175,888 award, effective September 1, 2024 through August 31, 2028, will enable the development of novel transcriptome-connectome analysis methods to identify genes associated with changes in brain functional connectivity related to addiction. The...
This Project Grant award of $397,829 from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports the development of an AI platform to discover new therapeutics for substance use disorders (SUDs). The key products and services to be delivered include: Creating a set of curated training datasets and machine learning (ML) models to accelerate drug discovery tasks for SUDs. Identifying mechanistic targets related to the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,251 to The Trustees of the University of Pennsylvania to develop a novel "released markers of activity" (RMAs) blood-based monitoring system for long-term tracking of neural circuit activity and opioid receptor gene expression changes in mice exposed to opioids. The goal is to better understand the molecular and functional...
This Project Grant award, valued at $395,995.00 and funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a longitudinal study investigating the reciprocal relationship between cannabis use, sleep, and the hypothalamic-pituitary-adrenal (HPA) axis. The study, to be conducted by Oregon Health & Science University (OHSU), will utilize a mixed-method approach combining ecological momentary assessments, continuous...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $715,238.00 to the University of California, San Diego (UCSD) to conduct a multivariate genome-wide association analysis of opioid-related traits in a diverse population of 500,000 individuals. The goal is to improve understanding of the genetic basis of opioid use disorder (OUD) and related pre-addiction stages, such as initial opioid use,...