Project Grant R21DA061547

Award Date 7/15/24
Completion Date 6/30/26
Dollars Obligated $693K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Durham, NC 27715, USA
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This $180,646 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the molecular mechanisms underlying astrocytic CREB's regulation of cocaine drug-seeking behavior. The principal investigator will build an independent research program to elucidate the transcriptional and epigenetic regulation of astrocytes in the context of drug abuse and addiction. Key activities include...
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The project will use innovative molecular genetic techniques to define changes in the 3D chromatin architecture and gene expression in VTA dopamine neurons following forced abstinence from chronic cocaine exposure. The researchers will then test the causal role of BDNF transcription in the VTA in driving cocaine-seeking behaviors in a mouse model of cocaine craving. The findings could provide circuit-level insights into the persistent neuroadaptations underlying addiction. A sub-award of $303,003 to the University of California, Irvine will contribute their expertise in mouse cocaine self-administration and epigenetic studies to this collaborative research effort.

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