Project Grant R01DA059542

Award Date 7/1/24
Completion Date 4/30/29
Dollars Obligated $1.9M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Boys Town, NE 68010, USA
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This Project Grant award for $1,032,192 was provided by the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The project aims to conduct a comprehensive, cell-type based epigenomic analysis to identify druggable genes for people living with HIV infection who also use cannabis. The research will involve profiling DNA methylation patterns across five different cell types isolated from peripheral blood mononuclear cells, alongside...
This Project Grant award, totaling $788,615, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research at Father Flanagan's Boys' Home in Boys Town, Nebraska to investigate the neural dynamics underlying cognitive decline associated with Alzheimer's spectrum conditions and HIV-related brain dysfunction. The key...
This federal Project Grant award, valued at $5,147,311 and issued by the National Institute on Drug Abuse (NIDA, CFDA 93.279 - Drug Use and Addiction Research Programs), supports research to investigate the impact of HIV infection and cocaine use on the integrity of the blood-brain barrier (BBB) in people living with HIV (PLWH). The key objectives are to: 1) Determine how immune cell phenotypes and HIV proviral DNA burden in monocytes and T cells contribute to BBB permeability in PLWH with and...
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This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,920,359 in funding to Father Flanagan's Boys' Home in Boys Town, NE to conduct research on the neurological impact of HIV and cannabis use.

The primary objectives are to use next-generation magnetoencephalography (MEG) imaging to quantify cortical-subcortical brain dynamics in persons with HIV (PWH), and evaluate how cannabis use may modulate these neural deficits. This research aims to address the lack of diagnostic tests and biomarkers to precisely assess the neurological complications of HIV, as well as the unclear role of substance use disorders in the elevated cognitive impairment seen in PWH. The 5-year project period runs from July 1, 2024 through April 30, 2029.

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