This Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 10-week randomized study to characterize the proximal relationship between cannabis use, intoxication, withdrawal, and changes in depressive symptoms and suicidal ideation among 200 school-based adolescents, aged 12-18 years, with daily or near-daily cannabis use, current depression, and recent suicidal ideation. The $2,286,303 award...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $656,121 to The Johns Hopkins University to investigate the impact of adolescent cannabis use on prefrontal cortex maturation and cognitive function. The key objectives of the research are to: 1) Identify the molecular and morphological changes in microglia induced by adolescent THC exposure via cannabinoid receptor type 1 (CNR1) signaling;...
The National Institute on Drug Abuse (NIDA) awarded Brown University a 5-year, $2,838,472 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to conduct a prospective mixed-methods investigation on using behavioral economic domains to characterize cannabis use trajectories among young adults. The research aims to identify factors that influence the time course of cannabis use patterns and mechanisms underlying the transition from casual to hazardous use, with a focus on how...
This Project Grant award of $1,362,860 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a study on the co-use of cannabis and prescription opioids among emerging adults in medical settings. The study aims to identify individual risk factors and malleable protective factors that contribute to the development of opioid and cannabis co-use and related problems in the context of pain management. The research will...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to assess the neurobehavioral impacts of medical cannabis use in adults aged 35-65 with chronic pain. The $663,150 award to the Regents of the University of Minnesota, through the Office of Sponsored Projects Administration, will fund a longitudinal observational study to evaluate cognition, neural function, and substance use disorder risk in...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $441,000.00 to Yale University to conduct research on the cellular and molecular mechanisms linking cannabis use disorder (CUD) and major depressive disorder (MDD). The project aims to identify genomic and epigenomic changes in the brain that may contribute to the development of MDD following CUD. Key activities include: Using single-cell...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on investigating the effects of early-life cannabinoid exposure on the development of the prefrontal cortex and cognitive behaviors in mice. The total funding amount is $1,433,155, with the award period running from June 1, 2024 to March 31, 2029. The key objectives of this research project are to: 1) reveal the spatial and...
This $233,250 Project Grant was awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University in St. Louis. The grant will fund a 2-year data analysis study to examine the relationship between early cannabis use and subsequent opioid use disorder, including the potential roles of adverse childhood experiences, genetic liability, and comorbid stimulant use. The project aims to provide insights into whether...
This Project Grant award, valued at $1,331,649.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2024. The grant supports research to investigate the bidirectional relationship between circadian rhythms and cannabinoid use, with a focus on understanding the molecular and cellular mechanisms underlying this interaction. The key objectives are to: 1) Determine how cannabinoid self-administration affects cell...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $376,078.00 to The Regents of the University of Colorado (CU) to conduct an experimental study on the antecedents and consequences of cannabis use for coping purposes. The study aims to examine whether cannabis use increases after stress induction among individuals who use cannabis to cope, as well as investigate if social anxiety,...
This $713,908 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a 5-year study investigating the neural and psychiatric consequences of cannabis use in depressed adolescents. The research aims to understand how cannabis use affects reward and pain neurocircuits, particularly the role of the habenula, and how this may impact depression chronicity in this population. The study will prospectively evaluate 250 adolescents across a range of depression and cannabis use severity, as well as 30 healthy controls, conducting comprehensive clinical assessments, daily cannabis use surveys, biomarker testing, and neuroimaging at baseline and 12-months. This research seeks to address a critical knowledge gap and inform prevention and intervention strategies for this vulnerable population.