The federal Project Grant award R01DA061223, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to examine the effects of cannabis use and discontinuation on sleep physiology and circadian rhythms in young adults aged 18-25. The $2,264,782 award will be used to study homeostatic sleep drive, circadian photosensitivity, and circadian phase in 60 regular cannabis users, as well as a control group of 30...
The National Institute on Drug Abuse (NIDA) awarded a $483,056 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Massachusetts Medical School to conduct research on the mechanisms linking opioid addiction, sleep, and circadian rhythms. The primary goals are to investigate the roles of the circadian transcription factor NPAS2 and dopamine D3 receptor signaling in the nucleus accumbens in controlling opioid craving and relapse behaviors. The...
This $443,263 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 5-year study on the relationship between cannabis use and sleep in women of childbearing age. The research team at Rutgers University will conduct a 60-day prospective study with 100 female cannabis users to characterize the effects of acute cannabis exposure on sleep physiology, including brain activity (EEG), autonomic nervous...
This $713,908 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a 5-year study investigating the neural and psychiatric consequences of cannabis use in depressed adolescents. The research aims to understand how cannabis use affects reward and pain neurocircuits, particularly the role of the habenula, and how this may impact depression chronicity in this population. The study will prospectively...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on investigating the effects of early-life cannabinoid exposure on the development of the prefrontal cortex and cognitive behaviors in mice. The total funding amount is $1,433,155, with the award period running from June 1, 2024 to March 31, 2029. The key objectives of this research project are to: 1) reveal the spatial and...
This federal Project Grant award of $100,267, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the developmental effects of cannabinoid exposure, including tetrahydrocannabinol (THC) and cannabidiol (CBD), on neuroinflammation and behavioral outcomes in a zebrafish model system. The research, conducted by the University of Mississippi, aims to define the sensitive developmental...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training) provides $350,000 in funding to Creighton University to investigate the developmental effects of environmental enrichment on the sensitivity to minor cannabinoid drugs such as delta-8-THC and CBD. The key objectives are to 1) determine if adolescent exposure to high- or low-novelty environments can alter the behavioral response to these cannabis-derived...
The federal Project Grant award of $360,100.00 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research on the "Socio-Structural Determinants of Cannabis and Derived Psychoactive Cannabis Product Use and Consequences Among Young Adults." The project, awarded to George Washington University, aims to advance scientific understanding of cannabis and derived cannabis product use patterns and...
This federal Project Grant award, valued at $220,340.00 and provided by the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs), supports research to investigate the role of microglia as a mechanism for the cognitive deficits associated with adolescent cannabis use. The research, conducted by Washington State University, aims to determine whether microglial activation is necessary for the cannabis-induced cognitive flexibility impairments observed in...
The National Institute on Drug Abuse (NIDA) awarded Brown University a 5-year, $2,838,472 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to conduct a prospective mixed-methods investigation on using behavioral economic domains to characterize cannabis use trajectories among young adults. The research aims to identify factors that influence the time course of cannabis use patterns and mechanisms underlying the transition from casual to hazardous use, with a focus on how...
This Project Grant award, valued at $1,331,649.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2024. The grant supports research to investigate the bidirectional relationship between circadian rhythms and cannabinoid use, with a focus on understanding the molecular and cellular mechanisms underlying this interaction.
The key objectives are to: 1) Determine how cannabinoid self-administration affects cell type-specific molecular rhythms in the nucleus accumbens (NAc) and sleep/wake rhythms in a rat model; 2) Assess whether cell type-specific molecular rhythm disruption in the NAc is sufficient to cause changes in cannabinoid self-administration; and 3) Analyze how molecular rhythms are altered in distinct cell types of the NAc using single nucleus RNA sequencing in subjects with cannabis use disorder. This research aims to provide insights into the neurobiology of cannabis use and identify potential new therapeutic targets and treatment strategies for cannabis use disorder.