This $1,997,979 Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to identify the genetic mechanisms underlying fentanyl addiction and incentive sensitization in mice. The overarching goal is to use the Collaborative Cross mouse panel, advanced behavioral assays, and multi-omics approaches to dissect the shared genetic drivers of fentanyl addiction, cocaine addiction, and incentive...
This $1,076,036 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant aims to characterize electroencephalography (EEG) signatures in the prefrontal cortex (PFC) following chronic opioid use and modulation of PFC interneurons. Specifically, the research will: Test if individual differences in PFC theta power and PFC interneuron physiology correlate with fentanyl self-administration and...
This $400,294 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the role of the serotonin 5-HT2A receptor in modulating the reinforcing value of the synthetic opioid fentanyl. The research aims to elucidate how adverse childhood experiences and chronic stress alter the rewarding aspects of fentanyl, with the goal of identifying a novel, non-opioid receptor target to control...
This $399,536 Project Grant was awarded by the National Institute on Drug Abuse (NIDA), a part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research to design, synthesize, and test non-opioid drug candidates that can help combat the national opioid crisis, with a focus on reversing the effects of synthetic opioids like fentanyl. The key goals are to: 1) Develop and characterize chemical lead compounds and control...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $340,000.00 to The Washington University in St. Louis, Missouri to conduct research on the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal and associated negative affective behaviors. The key objectives of this 2-year research project are to: 1) determine whether fentanyl withdrawal selectively modifies the...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $149,284 to the University of Washington to investigate the role of prefrontal cortex pyramidal neuron subpopulations in regulating drug-seeking behavior. The research will use fiber photometry and chemogenetic techniques to characterize alterations to intratelencephalic (IT) and pyramidal tract (PT) neuron activity in the prelimbic region of the...
This Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the interactions between the opioid fentanyl, non-opioid receptor mechanisms, and HIV/AIDS in the striatum region of the brain. The $3,904,555 award, which began on June 15, 2024 and will run through March 31, 2029, will identify the specific opioid, adrenergic, and other receptor mechanisms by which fentanyl and...
This Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will explore the neurobehavioral effects of concurrent opioid and methamphetamine use disorders. The $223,715 award, effective from July 2024 through February 2027, will support research conducted by the University of Washington to: Define the behavioral patterns and motivations underlying polysubstance addiction using a rodent self-administration...
This Project Grant award of $153,512 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to assess whether targeting the dentate gyrus region of the hippocampus can disrupt fentanyl-linked context memories and prevent relapse in addiction. The project has two key objectives: 1) to determine if inhibiting dentate gyrus neurons active during reward-context memory encoding can reduce drug-linked context memory recall, and 2) to...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $192,500 in funding to Wayne State University to conduct research on the effects of gestational fentanyl exposure on offspring development. The key objectives are to determine the impact of fentanyl exposure during pregnancy on offspring morbidity, mortality, developmental milestones, external morphology, brain volume, morphology, and...