Project Grant R01DA006227

This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $189,644 to Wake Forest University Health Sciences to functionally characterize and validate the roles of specific transcript variants of the dopamine D3 receptor (DRD3) gene in regulating cocaine-seeking and -taking behaviors. The research project aims to: a) determine the function of DRD3 transcript variants using heterologous expression systems,...

This $319,547 project grant awarded on September 15, 2023 by the National Institute on Drug Abuse (NIDA) under the Drug Abuse and Addiction Research Programs (CFDA 93.279) supports Afasci, Inc.'s research and development of a novel treatment for cocaine use disorder (CUD). The project will investigate the effects of Afasci's investigational new drug AFA-281, which inhibits both the T-type Cav3 ion channels and soluble epoxide hydrolase, on reducing cocaine-seeking behavior and hyperlocomotion in...

The University of Pennsylvania received a $527,837 Project Grant award from the National Institute on Drug Abuse, part of the Department of Health and Human Services, to study altered midbrain GABAergic circuitry and its role in driving greater cocaine self-administration. Specifically, the researchers will characterize the functional state of midbrain GABAergic circuitry and the disposition of the KCC2 potassium-chloride cotransporter during cocaine self-administration, extinction, and...

This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under CFDA 93.279 Drug Use and Addiction Research Programs, is supporting research to characterize the effects of ethanol on cocaine reinforcement and explore a potential pharmacotherapy for cocaine and alcohol co-use in a nonhuman primate model. The $242,310 award, with a project period from September 12, 2024 to March 31, 2027, will be executed by Wake Forest University Health Sciences, a leading academic...

This five-year, $573,638 project grant from the National Institute on Drug Abuse, part of the Department of Health and Human Services, supports research into the neural mechanisms of individual differences in cocaine avoidance. Funded under the Drug Abuse and Addiction Research Programs (CFDA 93.279), the grant to the Medical University of South Carolina will examine cellular mechanisms by which serotonin and glutamate receptors in the rostromedial tegmental nucleus drive aversive conditioning...

This federal Project Grant award of $149,284 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 (Drug Use and Addiction Research Programs) will support research to understand how chronic cocaine use disrupts the neural encoding of aversive stimuli in the brain. The key objectives are to: 1) Define the temporal parameters under which dopamine release modulates the activity of specific neuron populations in the nucleus accumbens, at baseline and in response to aversive...

This Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a $454,470 research initiative at Drexel University to examine epigenetic spatial architecture in the central nervous system (CNS) as a method to understand cocaine relapse in HIV-infected mice. The key objectives of this 2-year project are to: 1) develop an imaging pipeline to analyze tissue-level and nuclear-level spatial architecture...

This $492,000 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will fund a research project at the University of Chicago to elucidate the genetic and epigenetic factors underlying cocaine addiction. The key objectives of the project are to: 1) conduct high-resolution chromatin accessibility and DNA methylation profiling to delineate cell-type and circuit-specific epigenetic...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $720,741 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Missouri System to study the role of a brainstem-cerebellar circuit in sudden infant death syndrome (SIDS). The research aims to investigate how reduced serotonin receptor activity in this circuit may compromise cardiovascular recovery during life-threatening hypoxic events, leading to SIDS. The 4-year grant period runs...

This Project Grant award for $254,250, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to delineate the neural circuits and cell types involved in contextual memory and reward-seeking behavior related to cocaine addiction. The research, conducted by President and Fellows of Harvard College (Harvard Medical School), aims to characterize the intrinsic properties and transmission interactions of a...