Project Grant R01CA315861
- The National Cancer Institute awarded Mayo Clinic a cooperative agreement totaling $688,661 on June 9, 2026, to develop and validate cell-free DNA approaches for prospective detection and monitoring of malignant peripheral nerve sheath tumors (MPNST) and their precursor lesions in neurofibromatosis type 1 (NF1) patients under the Cancer Detection and Diagnosis Research program (CFDA 93.394). Mayo Clinic will conduct three integrated research objectives: determining whether integrative...
- The National Cancer Institute awarded Mayo Clinic $154,590 on January 10, 2026, for DNA aptamers as tools for toxin delivery to glioblastoma under the Cancer Research Manpower program (CFDA 93.398). The award funds research to develop DNA aptamer-drug conjugates (APDCs) that deliver monomethyl auristatin E (MMAE) toxin to glioblastoma tumors while overcoming blood-brain-barrier penetration and intratumoral heterogeneity obstacles. Aim 1 will identify glioblastoma-specific MMAE-conjugated DNA...
- The National Institutes of Health National Cancer Institute awarded $687,314 to Mayo Clinic Jacksonville on July 15, 2026, under the Cancer Treatment Research program (CFDA 93.395) to investigate senescence and resistance mechanisms in glioblastoma and to develop combination therapeutic strategies that overcome drug resistance. The funded research examines how glioblastomas develop resistance to mitotic kinase and kinesin inhibitors (ispinesib, alisertib, volasertib, and etoposide) through...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $219,510 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop noninvasive cell-free DNA biomarkers for early detection and treatment monitoring of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1. The research will integrate cell-free DNA epigenomic features—including methylation patterns and...
- The National Cancer Institute awarded Mayo Clinic Jacksonville $127,983 on August 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support mechanistically guided immunometabolic CAR-TIL therapy research for glioblastoma. The award funds development and evaluation of dual-engineered ME1-armored anti-PD-L1 CAR tumor-infiltrating lymphocytes in combination with intracranial administration of clemastine and bexarotene to address tumor heterogeneity and immune suppression in...
- The National Cancer Institute awarded Mayo Clinic $667,710 on March 20, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct a randomized Phase 2 trial evaluating blood-based tumor and immune markers for risk stratification and treatment response monitoring in oligometastatic castration-sensitive prostate cancer. The project integrates prostate cancer-derived extracellular vesicles and circulating tumor DNA as blood markers to identify patients who will benefit from...
- The National Cancer Institute awarded Emory University $402,401 on May 6, 2026, for development of an F-18 imaging agent to measure glioma IDH1 mutant expression under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The funded work develops a positron emission tomography tracer to non-invasively measure mutated cytosolic NADP+-dependent isocitrate dehydrogenase (IDH1) activity in low-grade glioma and secondary glioblastoma multiforme. IDH1 mutations occur in more than 70...
- The National Cancer Institute awarded Mayo Clinic Jacksonville $620,671 on June 23, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop and test a bioresorbable implant for local delivery of chemotherapy to aggressive meningiomas. The project addresses treatment limitations in meningioma management. Meningiomas are the most common adult central nervous system tumors, with over 36,000 diagnosed annually in the United States. Current treatment—maximal safe surgical resection...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic Jacksonville $599,699 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop chimeric antigen receptor T-cell and tumor-infiltrating lymphocyte immunotherapies targeting glioblastoma. The research applies a "double-hit" strategy combining two adoptive T-cell therapies administered via Ommaya reservoir to bypass the...
- The National Cancer Institute awarded The Medical College of Wisconsin, Inc. $602,121 under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on June 1, 2026, to develop and validate advanced radio-pathomic mapping techniques that predict pathological tumor characteristics in glioblastoma using standard clinical MRI. The research addresses non-enhancing tumor regions that extend beyond visible MRI enhancement and harbor resistant cells serving as recurrence reservoirs, regions...
The National Cancer Institute awarded Mayo Clinic $565,423 on August 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate individualized DNA junction-based liquid biopsies for monitoring glioblastoma and high-grade gliomas during and after treatment. The research addresses a clinical gap in glioma surveillance. Current magnetic resonance imaging monitoring using RANO 2.0 criteria lacks sensitivity and specificity for detecting early disease changes, and repeated tissue biopsies are not feasible. The project leverages tumor-specific DNA junctions—unique genomic breakpoints formed by tumor rearrangements—as individualized biomarkers detectable in blood plasma and cerebrospinal fluid. Prior work demonstrated that high copy amplified junctions are detectable in plasma from patients with high-grade gliomas with abundance correlating to disease burden and treatment response; however, plasma-based monitoring is limited to approximately 50% of patients. Low-copy junctions are nearly ubiquitous across gliomas and reliably detectable in cerebrospinal fluid, offering broader applicability. Increasing use of intraventricular cerebrospinal fluid access devices in neuro-oncology provides opportunity for longitudinal junction-based monitoring. Aim 1 will determine clinical utility of patient-specific DNA junctions in cerebrospinal fluid for monitoring glioma during standard-of-care treatment, assessing their accuracy in detecting decreased disease burden with cytoreductive therapy, their stability during surveillance of stable disease, and their ability to discriminate true progression from pseudoprogression. Aim 2 will compare plasma and cerebrospinal fluid as complementary monitoring modalities. The award period runs through July 31, 2031, with place of performance in Rochester, Minnesota.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $565.4k | 7/24/26 |