Project Grant R37CA311064
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $413,808 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) for the period August 1, 2026 through July 31, 2028. The grant supports research aimed at inducing neuroplasticity to improve surgical outcomes for patients with primary brain tumors (gliomas). The research utilizes a wireless cranial implant (Responsive Neurostimulation System)...
- Federal Project Grant Award Summary Massachusetts General Hospital (MGH), through its Research Management Division, received a $707,798 project grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through March 31, 2031. The award funds research to determine mechanisms of heterogeneous treatment response in glioblastoma (GBM), an aggressive brain tumor that typically recurs in treatment-refractory form shortly after...
- Federal Grant Award Summary Brigham & Women's Hospital received a $3.16 million Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded on August 14, 2025, with performance through July 31, 2029. The project develops and validates magnetic resonance fingerprinting (MRF) technology to non-invasively image glutamate metabolism in glioblastoma and other brain tumors. The research addresses a critical clinical need by...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $234,000 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the period August 1, 2025 through July 31, 2027. The project, titled "Whole-Brain Radiopathmic Mapping of Glioblastoma Infiltration," supports advanced biomedical research aimed at developing innovative diagnostic and analytical approaches to characterize glioblastoma tumor...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of California, Los Angeles a $640,597 Project Grant under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period of June 1, 2026, through May 31, 2031. This research initiative focuses on developing and validating advanced diagnostic and therapeutic approaches for glioblastoma (GBM), particularly isocitrate dehydrogenase wild-type cases that demonstrate resistance to current...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $382,449 Project Grant to the University of California, Los Angeles under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 16, 2025, with completion targeted for June 30, 2027. This research project develops and validates advanced dual-nuclei magnetic resonance imaging (MRI) techniques to non-invasively differentiate between recurrent brain metastases (RBM) and radiation-induced necrosis (RN)...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $603,981 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded August 18, 2025, with completion targeted for July 31, 2030. This research initiative develops and validates integrated clinical-grade artificial intelligence (AI) biomarkers combining genomic and digital pathology analysis to improve risk stratification and treatment...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Medical College of Wisconsin, Inc. a Project Grant totaling $632,314 under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026, through March 31, 2031. This award supports research and development of gallium maltolate (GAM), an iron-mimetic metallocompound, as a novel therapeutic intervention for difficult-to-treat pediatric central nervous system (CNS) tumors, specifically pediatric high-grade...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a $399,829 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop novel research models for investigating sex-based disparities in glioblastoma (GBM). The award, effective July 7, 2025 through June 30, 2027, funds the creation of investigative tools and methodologies to examine how sex chromosomes and sex hormones influence GBM phenotype, proliferation, and...
- Summary of Federal Project Grant Award The Medical College of Wisconsin, Inc. received a $494,160 project grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded on September 11, 2025, with a completion date of August 31, 2030. This five-year research initiative investigates the role of fragile X mental retardation autosomal related protein-1 (FXR1) messenger RNA (mRNA) encapsulated within extracellular vesicles (EVs) and its impact on...
The Medical College of Wisconsin, Inc. received a $602,121 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on June 1, 2026, with completion targeted for May 31, 2031. This research initiative develops and validates advanced radio-pathomic mapping techniques to improve detection and characterization of non-enhancing tumor regions in glioblastoma (GBM), a highly aggressive primary brain tumor with median survival of 12-15 months despite intensive multimodal therapy. The project leverages the world's largest neuro-oncology brain bank to create comprehensive tumor habitat maps that integrate imaging analysis with cellular morphometry and molecular markers including KI-67, CD68, and SOX2. The deliverables include retrospective analysis of tumor progression patterns examining clinical, demographic, and treatment factors impacting enhancing and non-enhancing tumor growth dynamics; development of second-order radio-pathomic maps that improve non-enhancing tumor detection; and creation of novel prognostic tools for personalized GBM management that substantially improve pathological resolution beyond previously developed models. These outputs are intended to identify previously unrecognized therapeutic targets in tumor microenvironments and enable improved patient stratification and treatment selection for this aggressive malignancy.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $602.1k | 5/26/26 |