Project Grant K08NS144524
- The National Cancer Institute awarded Mayo Clinic a cooperative agreement totaling $688,661 on June 9, 2026, to develop and validate cell-free DNA approaches for prospective detection and monitoring of malignant peripheral nerve sheath tumors (MPNST) and their precursor lesions in neurofibromatosis type 1 (NF1) patients under the Cancer Detection and Diagnosis Research program (CFDA 93.394). Mayo Clinic will conduct three integrated research objectives: determining whether integrative...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded Mayo Clinic Jacksonville $242,580 on August 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to decode and target the molecular mechanisms of TRAF7/KLF4 driver mutations in meningioma. The project uses CRISPR-CAS9 gene editing to introduce...
- The National Institute of Neurological Disorders and Stroke awarded Cincinnati Children's Hospital Medical Center $445,500 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct genetic dissection of the rasopathy gene NF1 and MAPK pathway activation in cortical cell fate. The research investigates mechanisms regulating early stages of gliogenesis from cortical progenitors using mouse models. Three specific...
- The National Cancer Institute awarded Mayo Clinic $565,423 on August 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate individualized DNA junction-based liquid biopsies for monitoring glioblastoma and high-grade gliomas during and after treatment. The research addresses a clinical gap in glioma surveillance. Current magnetic resonance imaging monitoring using RANO 2.0 criteria lacks sensitivity and specificity for detecting early disease...
- The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $622,784 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate acute and chronic repercussions of spinal cord stimulation following spinal cord injury. The research quantifies blood pressure instability after spinal cord injury, which interrupts descending autonomic regulatory signals and causes loss of consciousness, stroke,...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $195,625 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a human schwannoma-on-chip platform for real-time monitoring of tumor-nerve interactions. Schwannomatosis is a rare neurological disease characterized by peripheral nerve tumors that cause debilitating pain and progressive neurological deficits, with current...
- The National Institute of Neurological Disorders and Stroke awarded the Sloan-Kettering Institute for Cancer Research $484,000 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research characterizing and inhibiting interactions of the alpha-secretase ADAM17 with the neuronal-myelin signaling complex upon spinal cord injury. The study investigates how myelin-associated inhibitors—including...
- The National Cancer Institute awarded the Trustees of Indiana University $137,576 on January 21, 2026, under the Cancer Research Manpower program (CFDA 93.398) to fund research evaluating the role of T cells in neurofibromatosis type 1 (NF1)–associated peripheral nerve sheath tumor progression. The research examines molecular and cellular interactions governing progression along the peripheral nerve sheath tumor continuum, specifically investigating how alterations in immune surveillance...
- The National Cancer Institute awarded the Trustees of Indiana University $113,244 on December 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to conduct research on regulators of differentiation failure in NF2-mutant neural progenitors as a mechanism underlying spinal ependymoma formation. The recipient will perform a CRISPR kinase and transcription factor knockout screen in a neuroepithelial stem cell model with induced NF2 mutations to identify regulatory components...
- The National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health, awarded $613,912 to the Trustees of Indiana University on April 8, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to identify DLK1 as a biomarker for malignant peripheral nerve sheath tumor (MPNST) risk stratification in neurofibromatosis type 1 patients. The research addresses the clinical...
The National Institute of Neurological Disorders and Stroke awarded Mayo Clinic $219,510 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop noninvasive cell-free DNA biomarkers for early detection and treatment monitoring of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1. The research will integrate cell-free DNA epigenomic features—including methylation patterns and inferred nucleosome positioning—to create a cell-free DNA malignancy risk score that quantifies malignant potential across the spectrum of peripheral nerve sheath tumors from benign neurofibromas to malignant forms. In parallel, patient-derived xenograft models will relate cell-free DNA trajectories from serial nonterminal samples to tumor growth and pathway activity during targeted therapy to monitor treatment response and resistance in real time. The project supports the career development of the principal investigator under mentorship from Dr. Aadel Chaudhuri, an expert in cell-free DNA analysis, with targeted training in cell-free DNA fragmentomics and epigenomics, patient-derived xenograft modeling, and bioinformatics. Work is performed in Rochester, Minnesota. The period of performance runs from September 1, 2026, through August 31, 2031. This is a project grant under the assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $219.5k | 8/31/26 |