Project Grant R01CA314197
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $988,224 Project Grant to the University of California, San Diego effective September 1, 2025, through August 31, 2029, under the Cancer Treatment Research program (CFDA 93.395). This funding supports clinical research activities advancing therapeutic strategies for head and neck cancer patients who are medically unfit for standard treatment, with particular focus on older populations and medically underserved...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $650,597 Project Grant to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) for the period April 1, 2026 through March 31, 2031. This research initiative investigates the role of B-cells in generating durable complete responses to checkpoint blockade immunotherapy in head and neck squamous cell carcinoma (HNSCC). The project will deliver three primary research outputs:...
- Federal Grant Award Summary The National Cancer Institute awarded University of California, San Diego a $699,929 Project Grant on June 20, 2025, under the Cancer Treatment Research program (CFDA 93.395) to enhance immunotherapy response in human papillomavirus negative head and neck squamous cell carcinoma (HPV-HNSCC). The project, which extends through May 31, 2030, focuses on improving dendritic cell (DC) migration to draining sentinel lymph nodes to enhance the efficacy of programmed...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $637,509 Project Grant to the University of California, San Diego (UCSD) on May 11, 2026, under the Cancer Biology Research program (CFDA 93.396) to support a five-year research initiative extending through April 30, 2031. This award funds fundamental research investigating how cancer cells achieve signaling autonomy—the ability to sustain growth in nutrient- and growth factor-deprived environments—through rewiring of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded UC San Diego a $661,721 Project Grant effective April 1, 2026, through March 31, 2031, under the Cancer Biology Research program (CFDA 93.396). This award supports research focused on systematic functional mapping and interrogation of intrinsically disordered regions (IDRs) in oncogenic proteins. The project will deliver comprehensive domain and residue-level perturbation screening of IDRs across approximately...
- Federal Grant Award Summary The University of California, San Diego received a $671,226 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded May 15, 2026, with completion targeted for April 30, 2031. The project, "Colorectal Cancer Therapies Introduced Through Engineered Native Bacteria," will develop a microbial platform technology using engineered native E. coli strains derived from human gut bacteria to deliver...
- Federal Grant Award Summary The University of California, San Diego received a $483,360 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective July 1, 2025 through June 30, 2030. The award funds research investigating novel precision therapies for oral cancer, specifically targeting systems vulnerabilities in the epidermal growth factor receptor (EGFR)/HER3/HER2 oncogenic signaling...
- Federal Grant Award Summary The National Cancer Institute awarded $411,206 to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) on May 14, 2026, with a project completion date of April 30, 2028. This Project Grant supports the development of small molecule inhibitors targeting the proton-sensing G protein-coupled receptor GPR68 as a novel therapeutic approach for pancreatic ductal adenocarcinoma (PDAC). The research addresses a critical clinical...
- Federal Grant Award Summary The National Cancer Institute awarded UC San Diego a $410,933 Project Grant (Cancer Treatment Research, CFDA 93.395) effective March 18, 2026, with completion targeted for February 29, 2028. The award supports the development of next-generation small interfering RNA (siRNA) therapeutics designed to address metastatic castration-resistant prostate cancer (mCRPC), a lethal disease driven by genetically altered forms of the androgen receptor (AR). The research focuses on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
The University of California, San Diego received a $694,643 Project Grant from the National Cancer Institute (CFDA 93.395, Cancer Treatment Research) awarded on May 7, 2026, with an ultimate completion date of April 30, 2031. The grant supports research targeting the Hippo-YAP/TEAD signaling network in head and neck squamous cell carcinoma (HNSCC). This project addresses the significant clinical challenge of high mortality rates and treatment-related morbidity in HNSCC patients, with research objectives focused on developing improved therapeutic approaches that may enhance the efficacy of immune checkpoint blockade (ICB) therapies and other treatment modalities. The research will be conducted at UC San Diego's La Jolla, California campus. Under the Cancer Treatment Research program, this award supports fundamental and applied laboratory and clinical research aimed at discovering and developing novel cancer treatment approaches. The grant funding will enable UC San Diego researchers to investigate molecular signaling pathways with the objective of translating findings into improved cancer treatment methods, consistent with the National Cancer Institute's mission to develop means to cure cancer patients and control disease in those who cannot be cured.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.6k | 5/7/26 |