Project Grant R50CA305194
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $699,929 to the University of California, San Diego (UCSD) for a research project titled "Enhancing Dendritic Cell Migration to Draining Sentinel Nodes to Improve Immunotherapy Response in HPV Negative HNSCC". The project aims to investigate how modulating the migration of activated dendritic cells from the primary tumor to sentinel lymph nodes can enhance the efficacy...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding to The Trustees of the University of Pennsylvania to support the development and implementation of NCI-sponsored clinical trials for rare cancers. The $122,610 award, which began in August 2025, aims to: Assist junior and mid-career oncology faculty in developing investigator-initiated studies, and Develop a program within the National Clinical Trials Network (NCTN) to design...
- This federal Project Grant award, funded by the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), supports efforts by a Columbia University researcher to develop and implement NCI-sponsored cancer clinical trials at the NCI-designated Herbert Irving Comprehensive Cancer Center (HICCC). The $193,926 award, with a project period from September 1, 2025 to August 31, 2030, will enable the researcher to: (1) develop novel HICCC investigator-led trials for...
- The University of Texas MD Anderson Cancer Center received a $2,457,127 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to support the "INHANCE: Imaging Innovation for Head and Neck Cancer Evaluation & Treatment Delivery" research project. The goal of this 5-year project, starting August 18, 2025, is to leverage advanced imaging and computational analysis to better predict, detect, prevent, and manage normal tissue injury in head and...
- The University of California, San Diego (UCSD) was awarded a $667,485 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program. The grant will fund a 5-year longitudinal study to characterize radiation-induced neurocognitive decline in glioma patients, uncover the underlying brain injury mechanisms using advanced imaging biomarkers, and identify risk and resilience factors that moderate the relationship between radiation...
- This $149,394 Project Grant was awarded on August 1, 2025 by the National Cancer Institute (NCI), part of the Department of Health and Human Services, under the federal Cancer Detection and Diagnosis Research program (CFDA 93.394). The grant supports research led by the University of California, Davis to advance the development of targeted radiopharmaceuticals for cancer diagnosis and therapy. Specifically, the research focuses on designing, synthesizing, and optimizing novel molecular imaging...
- This $421,685 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate the "reactive" immune system in tumors and the tumor microenvironment. The study aims to discover discrete immune cell niches within the tumor that can enhance the effectiveness of cancer immunotherapies. Using innovative spatial transcriptomics, genetic tools, and cellular...
- This $714,062 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting research at the University of California, San Francisco (UCSF) to investigate the biological mechanisms contributing to racial disparities in oral and head and neck cancer outcomes, particularly among Black patients. The key research objectives are to: 1) develop a tailored RNA prognostic model to enhance oral cancer survival predictions in Black populations by identifying...
- This Project Grant award, funded by the National Cancer Institute (CFDA 93.395 Cancer Treatment Research), provides $1,295,508 to The Washington University to conduct research on drugging the NRF2 transcription factor to improve radiation therapy for head and neck squamous cell carcinoma. The project aims to evaluate two distinct NRF2 inhibitors - VVD065, a potent small molecule that induces NRF2 degradation, and pyrimethamine, an FDA-approved drug found to inhibit NRF2 signaling. Under a...
This federal Project Grant award of $988,224.00 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports the University of California, San Diego's research program focused on advancing treatment for head and neck cancer patients with competing health risks through multi-center randomized trials. The principal investigator has extensive experience leading national clinical trials through the NRG Oncology cooperative group and serving as co-chair of the NCI Head and Neck Steering Committee. The funding will enable the continued development and accrual of an NRG Oncology phase II randomized trial, as well as support the PI's roles in driving accrual to other NCI-sponsored head and neck cancer clinical trials. This award reflects UCSD's specialized capabilities in delivering innovative cancer research and treatment approaches through federally-funded collaborations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $988.2k | 8/28/25 |