Project Grant R01CA313995
- Summary of Federal Project Grant Award The Medical College of Wisconsin, Inc. received a $494,160 project grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded on September 11, 2025, with a completion date of August 31, 2030. This five-year research initiative investigates the role of fragile X mental retardation autosomal related protein-1 (FXR1) messenger RNA (mRNA) encapsulated within extracellular vesicles (EVs) and its impact on...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $602,121 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective June 1, 2026 through May 31, 2031. The grant funds research to develop and validate advanced radio-pathomic mapping techniques that predict pathological tumor characteristics in glioblastoma (GBM) using standard clinical MRI imaging. The project leverages the world's largest...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Wistar Institute of Anatomy and Biology a $473,624 Project Grant (CFDA 93.395: Cancer Treatment Research) effective April 3, 2026, through March 31, 2028, to investigate mechanisms of chemoresistance in metastatic ovarian cancer. The research focuses on elucidating the role of interleukin 1B (IL1B), a myeloid cell-derived inflammatory mediator, in promoting chemoresistance and developing therapeutic strategies to...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $156,000 Project Grant award dated June 18, 2025, from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a national cohort study examining breast cancer diagnostics, treatment, and outcomes in individuals using hormone therapy (HT). The project, which will be completed by May 31, 2027, will create a multi-institutional retrospective cohort of breast...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh $638,422 under the Cancer Biology Research program (CFDA 93.396) beginning May 1, 2026, through April 30, 2031. This five-year project grant funds fundamental research to elucidate the mechanisms of ovarian cancer metastasis, specifically examining the role of detachment sensing proteins in peritoneal spread. The research will identify and characterize essential genes within a...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $390,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with a completion date of March 31, 2031. This five-year investigator-initiated research project, titled "Metabolic Regulation of Immunity in C. Elegans," delivers fundamental biomedical research aimed at...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Alabama a $631,621 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an integrated top-down proteomics and phosphoproteomics platform for analyzing patient-derived ovarian cancer spheroids. The award, effective August 13, 2025, through July 31, 2028, supports the creation of personalized intact proteome maps that characterize disease states and identify markers...
- Federal Project Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded a $164,000 Project Grant to The University of Texas MD Anderson Cancer Center, effective September 1, 2025, through August 31, 2027. This award supports research investigating the clonal determinants of platinum/PARP inhibitor (PARPi) cross-resistance in high-grade serous ovarian cancer (HGSOC). The research utilizes a novel somatic mosaic genetically-engineered mouse model...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $1.098 million Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded on August 13, 2025, with a completion date of April 30, 2030. The funded research focuses on understanding the biological mechanisms controlling CD8+ tumor-infiltrating lymphocytes (TILs) and their progression through various functional states, including...
- Federal Project Grant Award Summary Case Western Reserve University received a $109,076 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 16, 2026, with completion targeted for August 31, 2029. The award supports research investigating the role of B-cell Activating Factor (BAFF) in adverse events associated with Chimeric Antigen Receptor (CAR)-T cell therapy. Specifically, the research examines BAFF's involvement in...
The Medical College of Wisconsin, Inc. received a $580,985 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to investigate the mechanisms by which B cell subpopulations influence high-grade serous ovarian cancer (HGSOC) progression and immunotherapy response. The research, which commenced on June 25, 2026, and is scheduled for completion by May 31, 2031, focuses on two primary objectives: (1) delineating the functions of B cell subtypes and their interactions with immune cells within the ovarian cancer microenvironment, and (2) determining how tumor-derived extracellular vesicles (EVs) influence B cell-mediated tumor progression. The project addresses a critical knowledge gap regarding why immunotherapies for HGSOC—which accounts for approximately 70% of ovarian cancer cases—have not achieved favorable response rates observed in other cancer types. The research employs advanced laboratory techniques including CITE-seq and paired immunoglobulin sequencing to characterize B cell dynamics, utilizing established HGSOC model systems and patient biospecimens to generate insights into B cell phenotypes, regulatory functions, and tumor immune evasion mechanisms. This fundamental research aims to identify novel targets for improving immunotherapeutic efficacy and to elucidate how tumor-derived EVs remodel the peritoneal B cell landscape to enhance immunosuppression and promote disease progression.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $581.0k | 6/30/26 |