Project Grant R01CA312067
- Federal Grant Award Summary The University of Pennsylvania received a $434,969 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) beginning May 1, 2026, and concluding April 30, 2031. This five-year research project investigates the cellular mechanisms underlying FLT3-mutant acute myeloid leukemia (AML) persistence during targeted therapy with FLT3 inhibitors. The research delivers fundamental mechanistic insights through an...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a $100,228 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on December 1, 2026, with a completion date of April 30, 2029. This award supports research training and career development activities focused on identifying immune mediators in BRCA1/2-deficient high-grade serous ovarian cancer (HGSOC). The project aims to elucidate the mechanisms driving immune...
- Federal Grant Award Summary The National Cancer Institute awarded a $122,610 Project Grant to the University of Pennsylvania on August 11, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award, with a completion date of July 31, 2030, supports the development of a system to advance National Cancer Institute (NCI)-sponsored clinical trials for patients with rare gastrointestinal malignancies and rare disease populations. The project leverages the principal investigator's...
- Federal Project Grant Summary The University of Pennsylvania received a $109,076 Project Grant awarded on January 30, 2026, by the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and career development in cancer research. The grant funds a research project titled "Exploring Metabolic Crosstalk Between Cancer Cells and Neutrophils in Pancreatic Ductal Adenocarcinoma," with completion scheduled for July 29,...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of The University of Pennsylvania a Project Grant of $126,220 under the Cancer Research Manpower program (CFDA 93.398) on September 10, 2025, with completion targeted for May 31, 2026. This award supports research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The project, conducted at the University of Pennsylvania in...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Pennsylvania a $703,071 Project Grant on April 10, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct research on the determinants of long-term CAR-T (chimeric antigen receptor T cell) cell persistence in blood cancer patients. The research will define the specific T cell characteristics and clones responsible for durable remissions in CAR-T cell therapy, with particular focus on...
- Federal Project Grant Award Summary Wayne State University received a $371,024 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through March 31, 2031. The award supports fundamental research investigating the essential roles of noncanonical signaling mechanisms of Janus Kinases 1 and 2 (JAK1 and JAK2) in mammary gland development and breast cancer. The research utilizes genetically engineered mouse models...
- Federal Project Grant Award Summary The University of Pennsylvania received a $667,041 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to validate and credential patient-derived xenograft (PDX) models of hepatocellular carcinoma (HCC). The project, which commenced April 1, 2026 and extends through February 28, 2031, focuses on developing rigorous validation and credentialing criteria for orthotopic HCC PDX models derived from...
- Federal Project Grant Award Summary The University of Pennsylvania received a $160,040 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective January 16, 2026, with a completion date of July 31, 2027. The award supports research investigating the therapeutic potential of Dectin-1 activation for treating gastrointestinal stromal tumors (GISTs), particularly in cases resistant to imatinib therapy. The project leverages innate...
- Federal Project Grant Award Summary The National Cancer Institute awarded the University of Pennsylvania a $658,033 Project Grant effective June 1, 2026 through May 31, 2031 under the Cancer Cause and Prevention Research program (CFDA 93.393). This research project focuses on developing translatable cancer interception strategies to interrupt the natural history of pancreatic ductal adenocarcinoma (PDAC) in high-risk patients. The grant supports research investigating mechanisms to eliminate...
The University of Pennsylvania received a $523,544 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026 through May 31, 2031. This five-year research initiative investigates the role of Janus kinase (JAK) inhibition in quiescent cancer cells and the tumor microenvironment, with particular focus on breast cancer recurrence mechanisms. The project delivers fundamental research aimed at understanding how JAK1/2 signaling regulates dormancy in residual tumor cells (RTCs), examining whether JAK inhibitor administration inadvertently accelerates cancer recurrence by forcing dormant cells back into the cell cycle. This research addresses a significant clinical concern given the large population of breast cancer survivors in the United States and the widespread use of JAK inhibitors for treating chronic inflammatory conditions. The grant supports investigative work utilizing genetically engineered mouse models that recapitulate human breast cancer dormancy and recurrence patterns. Research outcomes are expected to provide critical insights into cancer biology mechanisms that may inform clinical decision-making regarding JAK inhibitor administration to early-stage cancer patients with minimal residual disease, ultimately contributing to improved cancer prevention and treatment strategies as outlined in the Cancer Biology Research program objectives.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $523.5k | 5/22/26 |