Project Grant F31CA310488
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a $149,190 Project Grant on December 18, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and workforce development in cancer research. The grant funds an investigation into the role of tumor-intrinsic BCAT1 (branched-chain aminotransferase 1) in hepatocellular carcinoma (HCC) growth and anti-tumor immunity, with project completion...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Pennsylvania $178,893.00 under the Cancer Treatment Research program (CFDA 93.395) as a Project Grant effective September 1, 2025, through August 31, 2030. The award supports Dr. Naomi Haas's initiatives to develop and advance immunotherapy clinical trials in renal cell cancer (RCC) for potential integration into the National Clinical Trials Network (NCTN). As a genitourinary medical oncologist and Renal...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of The University of Pennsylvania a Project Grant of $243,888 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with completion targeted for July 31, 2027. This award funds research titled "Leveraging Innate Immunity for GIST Therapy," which investigates mechanisms to overcome imatinib resistance in gastrointestinal stromal tumors (GISTs). The research delivers...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded a $109,076 Project Grant to the University of Pennsylvania on January 30, 2026, with a completion date of July 29, 2027. This grant supports biomedical research training and workforce development focused on investigating metabolic crosstalk between cancer cells and neutrophils in pancreatic ductal adenocarcinoma (PDAC). The research employs spatial...
- Federal Grant Award Summary The National Cancer Institute awarded a $122,610 Project Grant to the University of Pennsylvania on August 11, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award, with a completion date of July 31, 2030, supports the development of a system to advance National Cancer Institute (NCI)-sponsored clinical trials for patients with rare gastrointestinal malignancies and rare disease populations. The project leverages the principal investigator's...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Wistar Institute of Anatomy and Biology a Project Grant totaling $473,624 (awarded April 3, 2026; completion March 31, 2028) under the Cancer Treatment Research program (CFDA 93.395) to conduct research on overcoming chemoresistance in metastatic ovarian cancer. The project will deliver fundamental research investigating how myeloid cell-derived interleukin 1B (IL1B) promotes chemoresistance in ovarian cancer...
- Federal Project Grant Award Summary The University of Pennsylvania received a $668,864 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded June 15, 2026, with completion targeted for May 31, 2031. This research initiative develops predictive biomarkers and resistance mechanisms for glioblastoma (GBM) patients undergoing dual-targeting chimeric antigen receptor (CAR) T cell therapy. The project leverages...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded the University of Pennsylvania $109,076 in Project Grant funding (Award Date: January 15, 2026; Completion Date: July 31, 2029) to support research investigating genes that limit Chimeric Antigen Receptor T (CAR T) cell persistence in solid tumors. The funded research focuses on identifying and characterizing genetic mechanisms—specifically the ATXN7L3 and...
- Federal Project Grant Award Summary The National Cancer Institute (National Institutes of Health) awarded The Trustees of The University of Pennsylvania a Project Grant of $594,899 under the Cancer Treatment Research program (CFDA 93.395) to conduct basic and translational research on glioblastoma (GBM) immunotherapy. The five-year research initiative, initiated July 6, 2026 and concluding June 30, 2031, focuses on understanding the vascular regulation of macrophage function in brain tumors...
- Federal Grant Award Summary The University of Pittsburgh received a $638,771 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2026, through May 31, 2031. This five-year award funds fundamental research investigating non-canonical functions of the mitochondrial fission protein DRP1 (dynamin-related protein 1) in high-grade serous ovarian cancer (HGSOC). The research focuses on understanding how a DRP1 splice variant...
The National Cancer Institute (NCI) awarded the University of Pennsylvania $100,228 under the Cancer Research Manpower program (CFDA 93.398) on December 1, 2026, for a project titled "Identifying Immune Mediators in BRCA1/2 Deficient High Grade Serous Ovarian Cancer." The award funds research training and investigator development through April 30, 2029. This project advances the NCI's mission to support biomedical training opportunities for individuals pursuing careers in cancer research aligned with the National Cancer Program. The research deliverables focus on identifying immune cells and signaling mediators that drive immune-suppressive tumor microenvironments and promote tumor progression in BRCA-deficient high-grade serous ovarian cancer (HGSOC). Using novel syngeneic BRCA-deficient HGSOC murine cell line models in immune-competent hosts, the investigator will conduct mechanistic studies examining the relationship between BRCA deficiency, inflammatory signaling, and immune suppression. Preliminary data indicates that inflammasome activity and caspase-1 signaling—rather than type 1 interferon signaling—may drive immune suppression, with caspase-1 inhibition showing promise in extending survival. These findings may inform combination therapeutic strategies involving poly (ADP-ribose) polymerase inhibitors and immunotherapy for treating HR-deficient ovarian cancers.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 4/6/26 | ||
| Not listed | $0 | 4/6/26 | ||
| Not listed | $50.1k | 4/6/26 |