Project Grant R01CA303474
- Federal Project Grant Summary The University of Pennsylvania received a $109,076 Project Grant awarded on January 30, 2026, by the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and career development in cancer research. The grant funds a research project titled "Exploring Metabolic Crosstalk Between Cancer Cells and Neutrophils in Pancreatic Ductal Adenocarcinoma," with completion scheduled for July 29,...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $123,823 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to the University of Maryland, Baltimore, effective June 1, 2026, through May 31, 2028. This grant supports research focused on characterizing transcriptomic, genomic, and microenvironmental heterogeneity in pancreatic precancerous lesions, specifically intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a Project Grant of $229,951 effective August 1, 2025, through May 31, 2030, under the Cancer Cause and Prevention Research program (CFDA 93.393). This grant provides salary support for Dr. Charly Good, a research specialist, to conduct research in the laboratory of Dr. Shelley Berger investigating mechanisms of gene regulation in cancer. The research focuses on understanding how...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of The University of Pennsylvania a Project Grant of $126,220 under the Cancer Research Manpower program (CFDA 93.398) on September 10, 2025, with completion targeted for May 31, 2026. This award supports research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The project, conducted at the University of Pennsylvania in...
- Federal Grant Award Summary The National Cancer Institute awarded a $122,610 Project Grant to the University of Pennsylvania on August 11, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award, with a completion date of July 31, 2030, supports the development of a system to advance National Cancer Institute (NCI)-sponsored clinical trials for patients with rare gastrointestinal malignancies and rare disease populations. The project leverages the principal investigator's...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a Project Grant of $408,829 under the Cancer Treatment Research program (CFDA 93.395) on May 25, 2026, with a completion date of April 30, 2028. This award funds investigative research into lipogenesis-mediated resistance to cytotoxic therapy in pancreatic ductal adenocarcinoma (PDAC). The research deliverables include characterization of de novo tumor lipid production following chemotherapy...
- Federal Project Grant Award Summary The University of Pennsylvania received a $667,041 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to validate and credential patient-derived xenograft (PDX) models of hepatocellular carcinoma (HCC). The project, which commenced April 1, 2026 and extends through February 28, 2031, focuses on developing rigorous validation and credentialing criteria for orthotopic HCC PDX models derived from...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a $100,228 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on December 1, 2026, with a completion date of April 30, 2029. This award supports research training and career development activities focused on identifying immune mediators in BRCA1/2-deficient high-grade serous ovarian cancer (HGSOC). The project aims to elucidate the mechanisms driving immune...
- Federal Grant Award Summary Purdue University received a $457,503 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on August 28, 2025, with completion targeted for July 31, 2030. The research project focuses on elucidating the posttranslational regulation of macropinocytosis in pancreatic ductal adenocarcinoma (PDAC), specifically investigating the role of protein phosphatase 2A (PP2A) subunit B56A in regulating nutrient-scavenging...
- Federal Project Grant Award Summary The University of Pennsylvania received a $523,544 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026 through May 31, 2031. This five-year research initiative investigates the role of Janus kinase (JAK) inhibition in quiescent cancer cells and the tumor microenvironment, with particular focus on breast cancer recurrence mechanisms. The project delivers fundamental research...
The National Cancer Institute awarded the University of Pennsylvania a $658,033 Project Grant effective June 1, 2026 through May 31, 2031 under the Cancer Cause and Prevention Research program (CFDA 93.393). This research project focuses on developing translatable cancer interception strategies to interrupt the natural history of pancreatic ductal adenocarcinoma (PDAC) in high-risk patients. The grant supports research investigating mechanisms to eliminate premalignant lesions—specifically pancreatic intraepithelial neoplasias (PanINs) and intraductal papillary mucinous neoplasms (IPMNs)—before they progress to invasive cancer, with particular emphasis on understanding and modulating the tumor microenvironment's protective mechanisms that facilitate malignant transformation. The research deliverables encompass translational mechanistic studies utilizing the KPC mouse model of PDAC to identify and validate potential intervention targets and therapeutic approaches that could be applied to interrupt disease progression in human populations. As part of the Cancer Cause and Prevention Research program's portfolio supporting cancer etiology, prevention mechanisms, and preventive interventions, this project contributes to the broader national objective of identifying risk reduction strategies and developing cancer prevention technologies applicable to one of the most lethal solid tumor types.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $658.0k | 5/26/26 |