Project Grant R01CA308968
- The National Cancer Institute awarded The Trustees of the University of Pennsylvania $415,623 on April 16, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop metabolic imaging capabilities using hyperpolarized agents at tracer concentrations. The recipient will design and build a low-cost, continuous-flow device capable of producing highly polarized imaging agents suitable for continuous infusion into cell culture and small animal preclinical experiments....
- The National Cancer Institute awarded The Trustees of the University of Pennsylvania $674,339 on June 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate translational imaging markers for enhancing immunotherapy efficacy in triple-negative breast cancer. The research addresses resistance to immune checkpoint inhibitor therapy in triple-negative breast cancer by targeting glutamine metabolism. The work will validate glutamine antagonism as a...
- The National Institutes of Health Office of the Director awarded the University of Pittsburgh $2 million on July 15, 2026, under the Research Infrastructure Programs (CFDA 93.351) to acquire a United Imaging uNeuroExplorer Brain PET/CT scanner. The scanner will replace a legacy Siemens ECAT EXACT HR+ PET scanner installed in 1996 and declared end-of-life by the manufacturer in 2013. The uNeuroExplorer is the only commercially available PET/CT scanner designed expressly for human brain imaging,...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California, Davis $615,615 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop next-generation whole-body positron emission tomography (PET) scanners with enhanced spatial resolution and timing performance. The research aims to achieve sub-2 millimeter spatial resolution and approximately 8 cubic millimeter...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $391,826 to the University of Pennsylvania on July 16, 2025, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate an innovative nanoparticle-based therapeutic platform for breast cancer treatment. The project, which extends through June 30, 2027, focuses on designing biodegradable polyphosphazene nanoparticles (PPNPs) that combine heat shock protein (HSP) inhibitor drug...
- The National Cancer Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of The University of Pennsylvania $668,864 on June 15, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The award funds development of a biomarker to predict patient response to chimeric antigen receptor (CAR) T cell therapy for glioblastoma and to identify mechanisms of tumor resistance to CAR T treatment. The research employs...
- The National Cancer Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of The University of Pennsylvania $618,063 on July 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop FLASH-CAR-T radioimmunotherapy for pediatric brain tumors. The project aims to advance immunomodulatory therapy for pediatric brain malignancies including medulloblastoma and glioma by combining FLASH proton beam radiation with...
- Federal Grant Award Summary The University of Pennsylvania received a $625,756 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective August 12, 2025 through July 31, 2028. This award supports development of BDEVS (Bead-based Digital Single Molecule-Single Extracellular Vesicle Sorting), a high-throughput microfluidic platform designed to advance early cancer detection through ultra-sensitive profiling of...
- The National Cancer Institute (NCI) awarded a $619,628 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The funding will support the development and validation of an autologous mouse model to study immune system interactions with glioblastoma, a type of brain cancer. The goal is to create a humanized mouse system that incorporates patient-derived tumor...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $499,516 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (NINDS, CFDA 93.853) to develop a novel imaging strategy for optimizing brain tumor immunotherapy. The recipient will develop a first-in-class small molecule positron emission tomography (PET) probe capable of crossing the blood-brain barrier and binding to perforin, a...
The National Cancer Institute awarded The Trustees of The University of Pennsylvania $672,995 on August 1, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop a high-performance brain PET scanner operating in tandem with a total-body PET system for oncologic imaging applications. The project, designated R01CA308968, runs through July 31, 2031, with place of performance in Philadelphia, Pennsylvania. The University of Pennsylvania, in partnership with Siemens, will develop and test a dedicated brain imaging instrument capable of sub-2-millimeter isotropic spatial resolution and approximately 160 picoseconds time-of-flight resolution. The scanner will operate as a standalone device for brain-only imaging and integrate with the PennPET Explorer total-body PET scanner to enable simultaneous high-resolution brain and body imaging for oncologic applications. The project comprises three specific aims: developing and testing the brain scanner performance and integration with the total-body system; adapting and evaluating image generation methods for quantitative brain imaging; and testing clinical performance and brain-body imaging protocols in human subjects using emerging tracers including 18F-FES, 18F-fluciclovine (FACBC), and 18F-FDG. Development will employ Monte Carlo simulations informed by experimental measurements, robust manufacturing practices, and physical performance characterization using phantom studies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $673.0k | 7/20/26 |