Project Grant R01NS143999
- Federal Grant Award Summary The Leland Stanford Junior University received a $424,234 Project Grant award dated May 16, 2025, from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research into in vivo tracking of innate immune activation and therapeutic response in multiple sclerosis (MS) mouse models utilizing [18F]OP-801, a novel fourth-generation...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a project grant of $125,685 on August 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research and development of a bioactive material intervention to address post-stroke dementia, a significant complication affecting approximately 7 million stroke survivors...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $209,177 Project Grant to The Leland Stanford Junior University beginning February 1, 2026, through January 31, 2031, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative focuses on identifying and targeting the MAP4K4 kinase pathway to inhibit tumor invasion in pediatric high-grade gliomas (PHGG), which are...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $943,253 to The Regents of the University of California, San Francisco on January 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This Project Grant supports preclinical research and development of breakthrough immunotherapy approaches for brain tumors, specifically malignant glioma. The research integrates multiple immune...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a $423,500 Project Grant effective August 1, 2025, through July 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This research initiative investigates the mechanisms underlying cognitive dysfunction in neuromyelitis optica (NMO), a central nervous system autoimmune disorder. The study will...
- Federal Grant Award Summary The Leland Stanford Junior University received a $1,151,209 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 15, 2025, with a completion date of June 30, 2030. This research initiative investigates a novel molecular driver of schwannoma nerve sheath tumors, specifically examining recurrent SOX10...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded The Leland Stanford Junior University a $131,085 project grant on June 9, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop an ultrasound-interrogated implantable sensor for intracranial pressure (ICP) monitoring. The research addresses the critical clinical need for non-invasive, reliable ICP monitoring in...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant of $122,526 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 7, 2025, with completion targeted for July 31, 2027. This research project investigates the phase separation of neuronal pentraxins and their role in synapse formation and synaptic plasticity. The...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Stanford University a $438,900 Project Grant effective April 1, 2025, through March 31, 2028, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports combinatorial engineering research to develop a three-cell synthetic immunotherapy system integrating T cells, natural killer cells, and macrophages, each...
- Federal Grant Award Summary The Leland Stanford Junior University received a $1.4M Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded August 15, 2025, with a completion date of July 31, 2028. This award supports research into combinatorial engineering of multicellular synthetic immunotherapy systems designed to overcome current limitations in engineered cell-based cancer treatments. The project...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $499,516 Project Grant to The Leland Stanford Junior University on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds development of a novel imaging strategy to enhance brain tumor immunotherapy treatment monitoring through September 2031. The research deliverables include development of a first-in-class small molecule positron emission tomography (PET) probe capable of crossing the blood-brain barrier and binding to perforin, a protein expressed exclusively by cytotoxic immune cells, to enable non-invasive visualization and differentiation between immunotherapy response and non-response in glioblastoma and other brain cancers. Specifically, Stanford will develop a library of fluorine-containing small molecules targeting perforin and advance the top-performing candidates for radiolabeling with fluorine-18. The project will characterize brain penetration, biodistribution, and stability of these radiotracers using quantitative benchmarks to advance the top three performers for treatment monitoring studies. This research addresses a critical clinical challenge: the inability to accurately distinguish tumor progression from treatment-associated inflammation using current contrast-enhanced magnetic resonance imaging protocols, thereby improving patient care and facilitating clinical development of immunotherapies for brain tumors.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $499.5k | 1/30/26 |