This federal Project Grant award of $391,826 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to develop a novel polyphosphazene nanoparticle (PPNP) platform for the enhanced treatment of breast cancer. The PPNP will be loaded with ultrasmall silver sulfide nanoparticles to provide strong photothermal therapy enhancement and imaging contrast, while also delivering a heat shock protein (HSP) inhibitor to the tumor. This low-cost, scalable platform synthesized by microfluidics is expected to improve the delivery of the HSP inhibitor, avoid cardiotoxicity, and enhance the effects of photothermal therapy on cancer killing. The project, awarded on July 16, 2025, will be conducted by The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, and is expected to be completed by June 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $391.8k | 7/16/25 |