Project Grant R01CA301255
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration within the School of Medicine a Project Grant totaling $109,076.00 under the Cancer Research Manpower program (CFDA 93.398) on December 17, 2025. The award supports biomedical research training and career development initiatives focused on cancer research through September 1, 2029. This project grant funds the institution's capacity to provide integrated...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration – School of Medicine a $110,228 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2026, through May 31, 2029. This grant funds a research initiative investigating how pancreatic ductal adenocarcinoma (PDAC) remodels the tumor microenvironment (TME) to facilitate metastatic outgrowth. The research addresses the critical...
- Federal Project Grant Award Summary The University of Miami's Office of Research Administration – School of Medicine Division received a $110,228 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2026, through May 31, 2030. This award supports the development and comparative evaluation of a novel class of chimeric ligand-presenting (CLIP) T cells designed to treat extranodal NK/T-cell lymphoma (ENKTL), a rare and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $669,278 to the University of Michigan's Office of Research and Sponsored Projects, effective June 1, 2026 through May 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This Multi-Principal Investigator (MPI) R01 application, aligned with PAR-25-107 (Advancing Microbial-Based Cancer Therapy), supports the development of engineered nonpathogenic tumor-tropic E. coli bacteria...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Miami $2.62 million under the Cancer Treatment Research program (CFDA 93.395) for a four-year project grant commencing August 1, 2025 and concluding July 31, 2029. This project grant supports fundamental and applied laboratory research to identify and develop cyclin-G associated kinase (GAK) inhibitors as a novel therapeutic approach for diffuse large B-cell lymphoma (DLBCL), a frequently diagnosed lymphoma...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $687,593 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on May 12, 2026, with completion targeted for April 30, 2031. The award funds fundamental cancer biology research investigating cysteine acquisition and utilization mechanisms in lung adenocarcinoma. The research will deliver scientific insights into how tumor cells...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration–School of Medicine a $254,333 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) effective September 23, 2025, through August 31, 2027. This award supports a comparative research study investigating racial disparities in breast cancer risk and gene expression by examining the roles of genetic and lifestyle factors across three...
- Federal Grant Award Summary The Medical University of South Carolina received a $616,624 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded May 18, 2026, with completion targeted for April 30, 2031. This award funds fundamental cancer biology research focused on exploiting inflammatory signaling pathways to target SETD2-deficient renal cell carcinoma (RCC). The research investigates how loss of SETD2, a histone...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $136,412 to the Regents of the University of Michigan, effective August 1, 2025 through July 31, 2027, under the Cancer Research Manpower program (CFDA 93.398). This award funds research aimed at defining and interrupting metabolic crosstalk in the glioblastoma microenvironment. The research builds upon preliminary findings demonstrating that glioblastoma (GBM) tumors acquire nutrients through...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Florida's Division of Sponsored Research a $487,056 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. This five-year initiative investigates the mechanisms by which inactivating mutations in the LKB1 (STK11) tumor suppressor gene drive immune evasion and therapeutic resistance in non-small cell lung cancer (NSCLC). The research...
The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration - School of Medicine Division a $529,260 Project Grant on June 22, 2026, under the Cancer Treatment Research program (CFDA 93.395) to investigate lactic acid sensing as a therapeutic vulnerability in clear cell renal cell carcinoma (CCRCC). The research examines the role of extracellular lactate in the tumor microenvironment and its function as a self-signal promoting tumor cell aggressiveness. The project identifies the G-protein coupled receptor GPR132 as a potential biomarker and therapeutic target, with research designed to elucidate downstream signaling mechanisms involving mitochondrial fidelity and HIF2A expression regulation. The award supports mechanistic research through pharmacologic and genetic approaches, with the ultimate goal of advancing clinical discovery that may impact treatment outcomes for metastatic CCRCC patients. The five-year project, with an ultimate completion date of May 31, 2031, will be conducted at the University of Miami in Miami, Florida. The research employs sophisticated laboratory techniques and vertebrate animal models to investigate the integrative metabolic signaling network within an intact tumor microenvironment. This work falls within the NCI's Cancer Treatment Research program scope, which supports discovery, development, and clinical testing of improved cancer treatment methods, including molecularly targeted biological therapies and fundamental laboratory investigations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $529.3k | 6/23/26 |