Project Grant R01CA299949
- Federal Grant Award Summary The National Cancer Institute awarded the Regents of the University of Michigan a $2.86 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) to develop and validate a novel microbial-based therapeutic strategy targeting colibactin, a carcinogenic metabolite produced by pathogenic gut bacteria associated with colorectal cancer (CRC). The project, which commenced September 10, 2025, and extends through August 31, 2029, focuses on engineering...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $544,868 to the Regents of the University of Michigan, Office of Research and Sponsored Projects, under the Cancer Treatment Research program (CFDA 93.395). The award, effective June 1, 2026, through May 31, 2031, supports fundamental research investigating the role of the SLC13A3 transporter and the metabolite itaconate in tumor resistance to immunotherapy. The research addresses a critical gap in...
- This $627,422 Project Grant award from the National Cancer Institute under the Cancer Treatment Research (CFDA 93.395) program supports research by the Regents of the University of Michigan to engineer commensal bacteria that can neutralize the colibactin genotoxin produced by certain gut bacteria associated with increased colorectal cancer risk. The key products and services to be delivered under this 5-year grant include: 1) Further optimization of the surface display of the anti-toxin...
- The University of Michigan received a $646,671 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) on May 15, 2026, for research extending through April 30, 2031. The grant funds research to identify and characterize novel payloads for antibody-drug conjugates (ADCs) that maximize multiple mechanisms of action, including immunogenic cell death and Fc-effector function. The project specifically develops high avidity low affinity...
- Federal Grant Award Summary The University of Michigan received a $660,808 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective April 7, 2026 through March 31, 2031. This award funds fundamental research investigating the durability and role of tissue-resident memory T cells (TRM) in melanoma immune responses and immunotherapy outcomes. The project examines how TRM cells, particularly a subset expressing high interferon gamma...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan $139,968 under the Cancer Research Manpower program (CFDA 93.398) on July 15, 2025, for a project period extending through June 30, 2027. This Project Grant supports biomedical research training and cancer-related research in basic and translational science aligned with the National Cancer Program priorities. The award funds a research initiative titled "Beyond Lysis:...
- Federal Grant Award Summary The University of Michigan's Regents received a $646,920 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective March 11, 2026 through February 28, 2031. This award supports fundamental and applied research focused on developing novel multi-targeted therapeutic strategies to address chemotherapy-resistant T-cell lymphomas (TCL) and their tumor microenvironment. The research investigates...
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $443,564 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded on September 2, 2025, with completion by August 31, 2027. The award supports the development of a novel cancer immunotherapy platform utilizing engineered commensal skin bacteria to stimulate tumor-specific T cell immunity. The research focuses on leveraging Staphylococcus epidermidis, a naturally...
- Federal Grant Award Summary The National Cancer Institute awarded the Regents of the University of Michigan a $640,135 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025 through July 31, 2030. This award supports the development of next-generation menin inhibitors designed to overcome clinical resistance observed in acute myeloid leukemia (AML) patients undergoing menin inhibitor therapy. The research addresses the critical clinical problem of...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $616,715 to The University of Texas MD Anderson Cancer Center, with an award date of August 11, 2025 and completion date of July 31, 2030. This award supports research under the Cancer Treatment Research program (CFDA 93.395), which develops and evaluates improved methods of cancer treatment through fundamental and applied laboratory and clinical research. The funded research centers on the...
The National Cancer Institute awarded the Regents of the University of Michigan a $669,278 Project Grant effective June 1, 2026, through May 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This research initiative develops microbial-based cancer therapy utilizing nonpathogenic, tumor-tropic Escherichia coli engineered to display membrane-anchored immune cytokines, specifically decoy-resistant interleukin-18, to enhance localized immune activation within solid tumors while minimizing systemic toxicity. The therapeutic approach addresses critical limitations in current cancer treatments, including poor efficacy of immune checkpoint inhibitors and chimeric antigen receptor (CAR) natural killer cell therapies in immunosuppressive tumor microenvironments. The project encompasses three primary research aims designed to elucidate mechanisms of tumor-localized immune activation, optimize cytokine engineering strategies, and evaluate synergistic efficacy in combination with established immunotherapies. Preliminary data demonstrates that the engineered bacterial therapy significantly improves immune cell infiltration, reduces systemic cytokine toxicity, and enhances CAR-NK cell therapy efficacy in preclinical mouse models. Research activities will be conducted at the University of Michigan's Ann Arbor campus, where the institution's extensive research infrastructure and expertise in cancer immunotherapy support the development and evaluation of this innovative therapeutic platform aligned with National Cancer Institute priorities for advancing microbial-based cancer treatment modalities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $669.3k | 6/1/26 |