Project Grant R01CA309659
- Federal Project Grant Award Summary The National Cancer Institute awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant totaling $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of June 1, 2026 through May 31, 2028. The research project focuses on discovering novel therapeutic targets and chemical leads to overcome epithelial-to-mesenchymal transition (EMT)-mediated resistance in epidermal growth factor receptor...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of September 1, 2025 through August 31, 2027. This award supports exploratory research into the role of antisense ribonucleic acids (asRNAs) in melanoma development and transformation. The project will deliver scientific research and analysis focused on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., a Project Grant of $734,942 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This project addresses cardiovascular disease (CVD) risk in breast cancer survivors by generating novel DNA methylation biomarker data from the Pathways Study, a prospective cohort of 4,504 women diagnosed with...
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $157,248 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and career development in cancer research. The award, effective September 1, 2025, through August 31, 2028, funds investigator-initiated research focused on understanding the oncogenic roles of alarmins and monocytes in triple...
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $607,249 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective May 1, 2026 through April 30, 2031. The grant supports research to define the role of MAFG (a transcription factor) in melanocyte transformation and melanoma development. The research will utilize an embryonic stem cell-genetically engineered mouse...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $1,098,920 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) for the period August 13, 2025 through April 30, 2030. The research focuses on understanding the transcriptional and epigenetic control of CD8+ tumor-infiltrating lymphocytes (TILs), with particular emphasis on characterizing how the transcription factor...
- Federal Grant Award Summary The National Cancer Institute awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant under the Cancer Research Manpower program (CFDA 93.398) in the amount of $123,182.00, effective July 17, 2025, with a completion date of June 30, 2027. This award supports a Pathway to Independence Award (K99/R00) research project investigating the mechanisms by which dormant disseminated breast cancer cells communicate with their surrounding...
- Federal Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $2.99 million Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded September 23, 2025, with a completion date of August 31, 2029. The grant supports a two-pronged research initiative to characterize lung cancer screening trends and outcomes among people with HIV (PWH) in the United States. The project leverages...
- Federal Grant Award Summary The National Cancer Institute awarded a $2.49M Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Sloan-Kettering Institute for Cancer Research, effective August 1, 2025, through July 31, 2030. This research initiative comprises three integrated projects investigating lipid metabolism as a determinant of ferroptosis sensitivity in cancer cells. Project 1, led by Dr. Xuejun Jiang at Memorial Sloan Kettering Cancer Institute, examines how...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $851,463 under the Cancer Cause and Prevention Research program (CFDA 93.393) for the five-year period from September 1, 2025, through August 31, 2030. The funded research project, "Harnessing Big Data to Understand the Confluence of HIV and Cancer Stigma in the US Southeast," will deliver a comprehensive investigation into how...
H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $687,593 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective May 12, 2026, with completion targeted for April 30, 2031. The award funds fundamental research investigating cysteine acquisition and utilization mechanisms in lung adenocarcinoma. The project delivers scientific research services aimed at understanding how tumor microenvironments regulate cysteine availability and cellular metabolism, with specific focus on glutathione (GSH)-mediated processes, cysteine transporter identification and characterization, and metabolic reprogramming pathways that bypass conventional cystine import mechanisms. The research employs advanced methodological approaches including quantitative metabolomics with optimized derivatization, in vivo stable isotope tracing, matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry, and specialized culture systems that replicate tumor microenvironment composition. The deliverables from this work are expected to identify novel therapeutic targets and provide insights into in vivo tumor metabolism that could inform development of more effective cancer treatments. As a Cancer Biology Research program award, the project directly supports the NCI's objective to provide fundamental information on cancer cause and nature with the expectation of advancing prevention, detection, diagnosis, and treatment methodologies for neoplastic diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $687.6k | 5/13/26 |