Project Grant R01CA299261

Award Date 4/11/25
Completion Date 3/31/30
Dollars Obligated $425K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Texas, USA
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  1. Molecularly characterize the drug-tolerant persister cells that emerge after standard platinum-based chemotherapy in SCLC models and patient samples.

  2. Evaluate the ability of a newly-approved bispecific T-cell engager (BiTE) targeting the DLL3 protein to shape or eliminate the post-platinum drug-tolerant persister cell population.

  3. Develop new antibody-based therapeutics, such as antibody-drug conjugates (ADCs) or chimeric antigen receptor (CAR) T-cells, that specifically target surface proteins enriched in the drug-tolerant persister cells that survive both platinum-based chemotherapy and DLL3 BiTE treatment.

The 5-year award period runs from April 11, 2025 to March 31, 2030 and will be conducted by the University of Texas MD Anderson Cancer Center, a prominent academic cancer research institution.

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