Project Grant R01CA287734

Award Date 8/1/24
Completion Date 7/31/29
Dollars Obligated $670K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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The research will leverage unique clinical trial cohorts, human-relevant mouse models, and advanced multi-omics technologies to determine the transcriptional, immunogenomic, and spatial landscapes of B lineage cells in NSCLC treated with neoadjuvant immune checkpoint inhibitor-based therapy. It will also interrogate the impact of B cells on T cell-mediated responses to this treatment approach in murine NSCLC models. Additionally, the project will investigate the utility of B cell-centric phenotypes in predicting benefit from neoadjuvant immune-based therapy in resectable NSCLC patients. The award is being provided to the University of Texas M.D. Anderson Cancer Center to conduct this 5-year research program.

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