This $670,358 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to investigate the role of B cell lineages in mediating response to neoadjuvant immune-based therapy for resectable non-small cell lung cancer (NSCLC). The research will leverage unique clinical trial cohorts, human-relevant mouse models, and advanced multi-omics technologies to determine the transcriptional, immunogenomic, and spatial landscapes of B lineage cells in NSCLC treated with neoadjuvant immune checkpoint inhibitor-based therapy. It will also interrogate the impact of B cells on T cell-mediated responses to this treatment approach in murine NSCLC models. Additionally, the project will investigate the utility of B cell-centric phenotypes in predicting benefit from neoadjuvant immune-based therapy in resectable NSCLC patients. The award is being provided to the University of Texas M.D. Anderson Cancer Center to conduct this 5-year research program.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $670.4k | 7/30/24 |