This $449,196 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research by the University of Texas Southwestern Medical Center to investigate mechanisms of therapeutic resistance in cancer. The research focuses on elucidating how inhibition of receptor tyrosine kinases (RTKs), a common targeted cancer therapy approach, can trigger adaptive responses in cancer cells that lead to secondary resistance. Specifically, the project will examine how TKI-induced sumoylation of RTKs, such as mutant EGFR in non-small cell lung cancer, reprograms their function to drive pro-survival signaling and bypass inhibition. The 5-year project aims to uncover the molecular mechanisms underlying this adaptive response and its impact on secondary resistance, with the goal of informing the development of more durable targeted cancer therapies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $449.2k | 3/27/25 |