Project Grant R01CA299080
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $615,399 Project Grant to the University of California, Davis under the Cancer Treatment Research program (CFDA 93.395) for the period August 1, 2025, through July 31, 2030. The award supports the development of a transformable nanoparticle (TNP) platform designed to deliver therapeutic peptides and proteins directly to tumor microenvironments on-demand. The TNP technology transforms from nanoparticles to nanofibrils...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Georgia State University Research Foundation Inc. a $406,258 Project Grant on July 15, 2025, under the Cancer Treatment Research program (CFDA 93.395) to develop novel covalent anti-cancer drugs utilizing phosphorus fluoride exchange (PFEX) click chemistry. The two-year research initiative, concluding June 30, 2027, focuses on designing privileged covalent warheads with expanded target scopes to overcome limitations of...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Florida a $2,628,974 Project Grant on August 15, 2025, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) to develop and validate nanotechnology-enabled quantitative imaging technology for tracking dendritic cell (DC) anti-cancer vaccines. The research project, which extends through July 31, 2029, centers on magnetic particle imaging (MPI)—an innovative imaging modality utilizing...
- Federal Grant Award Summary Award Details: Nanocan Therapeutics Corporation received a $1,997,562 Phase II Small Business Technology Transfer (STTR) Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded September 24, 2025, with completion scheduled for August 31, 2027. Products and Services: Under this award, Nanocan Therapeutics Corporation, in collaboration with Johns Hopkins University, will develop and clinically validate the...
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded a $638,120 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) beginning August 1, 2025, with an ultimate completion date of May 31, 2030. This award supports research to develop and evaluate improved methods of cancer treatment through laboratory and clinical investigation focused on neoantigen cancer vaccines using microbial...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Emory University a $156,500 Project Grant on August 1, 2025, under the Cancer Treatment Research program (CFDA 93.395) to conduct integrated multi-omics research exploring the pathophysiology of cachexia in head and neck squamous cell carcinoma (HNSCC) patients. The two-year project, concluding July 31, 2027, will investigate the systemic biological mechanisms underlying cancer cachexia through comprehensive analysis of...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $644,452 Project Grant to the University of Georgia Research Foundation, Inc. (UGA Research Foundation) on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The research will be conducted in Athens, Georgia, with a completion date of February 28, 2031. The project focuses on developing engineered synthetic low-density lipoprotein (LDL) nanoparticles...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $391,826 to the University of Pennsylvania on July 16, 2025, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop and validate an innovative nanoparticle-based therapeutic platform for breast cancer treatment. The project, which extends through June 30, 2027, focuses on designing biodegradable polyphosphazene nanoparticles (PPNPs) that combine heat shock protein (HSP) inhibitor drug...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
The National Cancer Institute awarded a $618,236 Project Grant to the University of Georgia Research Foundation, Inc. under the Cancer Treatment Research program (CFDA 93.395) to develop calcium nanoparticles designed to enhance radio-immunotherapy for cancer treatment. Awarded on March 24, 2026, with an ultimate completion date of February 28, 2031, this research initiative focuses on developing surface-engineered calcium nanoparticles (ACaNPs) that selectively deliver calcium to dendritic cells to improve their infiltration into tumors and migration to tumor-draining lymph nodes. The technology aims to enhance the efficacy of immune checkpoint blockade therapy by elevating dendritic cell populations and promoting maturation in the tumor microenvironment. The project will utilize murine models of head and neck squamous cell carcinoma (HNSCC) to evaluate the efficacy of combining calcium nanoparticle delivery with radiation and anti-PD-L1 immunotherapy. Research will be conducted at the University of Georgia's Athens, Georgia facility. If successful, this nanomedicine platform could extend to other solid cancers currently undergoing intensive clinical investigation, advancing treatment options for patients who do not respond effectively to standard immunotherapy alone.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $618.2k | 3/24/26 |