The University of California, Davis was awarded a $615,399 Project Grant by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to develop a transformable nanoparticle (TNP) platform capable of transforming into nanofibrillar networks that can effectively deliver immunomodulatory peptides, small molecules, and proteins to the tumor microenvironment. This 5-year research project aims to optimize the TNP/TCTS therapeutic platform for on-demand modulation of the tumor microenvironment and elicitation of a robust anti-tumor immune response, leading to durable regression of cancer. The award supports research across 3 specific aims: 1) designing and characterizing EGFR and A3B1 integrin-targeting TNP constructs, 2) using in vivo and ex vivo optical imaging to optimize the TNP/TCTS platform, and 3) evaluating the in vivo toxicity and efficacy of the TNP/TCTS immunotherapeutic approach in a syngeneic murine lung cancer model.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $615.4k | 7/23/25 |