Project Grant R01AT012910

Award Date 9/17/24
Completion Date 6/30/29
Dollars Obligated $445K
Federal Grant Program
93.213
Assistance Type
Project Grant
Place of Performance
Blacksburg, VA, USA
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This Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to improve the understanding of traumatic brain injury (TBI) biomechanics. The $559,820 award will enable the University of South Carolina, in collaboration with the Henry M. Jackson Foundation for the Advancement of Military Medicine, to conduct a multimodal study...
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The key objectives are to evaluate whether COMM can mitigate behavioral patterns seen following repetitive closed head brain injury using a preclinical model, and to measure brain fluid flow and inflammation with and without COMM treatment through biomedical imaging and molecular biology techniques. The study will include both male and female subjects to assess potential sex differences in neurological symptoms, injury severity, and fluid flow changes in the brain to help refine COMM treatment. The findings are expected to provide the first evidence for the clinically observed effects of COMM as an intervention for TBI and resulting acute and chronic symptoms.

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