Project Grant R01AR088245
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Trustees of Columbia University in the City of New York $100,228 on November 27, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research investigates the mechanotransduction pathways regulating tendon development, specifically the role of MRTF/SRF signaling in response to mechanical cues. The project integrates in vitro models using mouse embryonic stem...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $671,214 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate somatosensory nerve regulation of fracture repair. The research focuses on the role of tropomyosin receptor kinase A (TrkA)-positive sensory neurons in bone healing, specifically examining how these neurons regulate fracture repair through the release of...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Rochester $493,971 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to define the epitenon cell–gamma delta T cell axis in fibrotic tendon healing. The project addresses peritendinous adhesions that form between healing tendons and surrounding tissues, the leading cause of impaired recovery following tendon...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Pennsylvania $507,606 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846, Assistance Listing Project Grant). The research investigates how mechanical loading activates focal adhesion kinase (FAK)-mediated mechanotransduction in tendon cells within their native extracellular matrix environment. The project builds on preliminary findings showing...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Massachusetts General Hospital $243,192 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) on November 1, 2025. The award funds research investigating the role of Wnt signaling in the mechanical maturation of postnatal tendon. The research aims to elucidate cellular and molecular mechanisms by which Wnt signaling and Wnt-responsive cellular populations marked by Axin2 expression...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $543,417 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate functional neuromuscular regeneration following chronic volumetric muscle loss in aged mice. The research addresses the restoration of neuromuscular junctions after volumetric muscle loss, a critical-sized skeletal muscle injury in which natural healing...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of Colorado $348,339 on May 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research on the mechanical role of hyaluronic acid in tendon fibers and how glycosaminoglycan depletion affects strain recovery in collagen. The research employs laser ablation of collagen fibers within intact tendons and enzymatic treatments...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Wisconsin–Madison $198,460 on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project, titled "Advancing Rehabilitation of Patellar Tendon Injuries Using Innovative Wearable Technology and Quantitative Magnetic Resonance Imaging Techniques," develops methods to optimize rehabilitation and improve treatment outcomes for...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Duke University $124,875 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate muscle-to-bone communication during fracture repair and musculoskeletal regeneration. The research identifies pro-regenerative signals from injured muscle that orchestrate repair of both bone and muscle tissue. Preliminary findings...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Baylor College of Medicine $374,000 on August 17, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of the transcription factor TONEBP/NFAT5 in regulating chondrocyte energy availability and extracellular matrix synthesis during postnatal bone growth. The research examines how chondrocytes balance intense matrix production with protein quality...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Johns Hopkins University $697,369 on August 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate nerve-tendon crosstalk as a mechanism for enhancing tendon repair while mitigating pain-related responses. The project focuses on separating regenerative signaling pathways from pain signaling pathways following tendon injury. Research will examine how nerve growth factor (NGF) released from injured tendons activates TrkA-expressing sensory neurons, leading to fibroblast growth factor 1 (FGF1) release that promotes repair in tendon sheath progenitor cells and tenocytes. Preliminary findings indicate that mitogen-activated protein kinase interacting kinases (MNK1 and MNK2) mediate pain response downstream of NGF-TrkA signaling, and that inhibiting these kinases reduces tendon pain while preserving repair capacity. The research aims to determine whether selectively targeting MNK-dependent nociceptive pathways while preserving FGF1-dependent regenerative responses offers a novel therapeutic approach to tendon and ligament injury. Performance occurs in Baltimore, Maryland. The project period extends through June 30, 2031. This is a Project Grant, the standard NIH research award mechanism supporting investigator-initiated basic and clinical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $697.4k | 8/6/26 |