Project Grant R01AR087804
- Federal Grant Award Summary National Jewish Health received a $388,025 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) on June 1, 2026, with an ultimate completion date of May 31, 2028. The award funds research to develop novel murine and human models that elucidate the role of aberrant T cell subsets in systemic sclerosis-related pulmonary fibrosis,...
- Federal Project Grant Award Summary The University of Virginia received a $377,506 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective June 1, 2026 through May 31, 2028. The award funds research investigating the modulation of efferocytosis—the physiological clearance of apoptotic cells—in systemic sclerosis (SSC), an autoimmune disease...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded $637,567 to the Regents of the University of Michigan on September 19, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of A20 and DREAM proteins in adipogenesis and systemic sclerosis (SSC). The research will be conducted through August 31, 2030, and aims to elucidate the mechanisms of myofibroblast...
- Federal Project Grant Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Pittsburgh a Project Grant valued at $504,442 on September 2, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports a five-year research initiative (through August 31, 2030) to characterize molecular endotypes in pediatric scleroderma through integration of advanced genomic and histopathological...
- Federal Grant Award Summary The University of Houston System received a $667,276 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective May 20, 2026 through April 30, 2031. The project investigates gene-environment triggers and proteomic pathways that mediate the development of systemic autoimmune rheumatic diseases (SARDs), including rheumatoid...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded New Jersey Institute of Technology a $330,107 Project Grant effective September 1, 2025, through June 30, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports fundamental research investigating the role of stress anisotropy—directional stress differences in extracellular matrices—in fibroblast activation and its...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Leland Stanford Junior University a Project Grant of $102,341 on September 10, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award supports research on RNA-dependent protein assemblies in epidermal homeostasis, with completion targeted for June 30, 2027. The project addresses mechanisms of epidermal dysfunction...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $172,584 Project Grant to The Trustees of Columbia University in the City of New York to support a five-year career development program (September 1, 2025 – August 31, 2030) focused on identifying causal genes in systemic sclerosis (SSC) through multi-omics analyses. The funded research program aims to deliver scientific outputs including gene prioritization methodologies...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Texas Health Science Center at Houston a $1.39 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) on September 1, 2025, with a completion date of May 31, 2029. This research award supports investigation into ribosome dysfunction mechanisms in systemic sclerosis-associated interstitial lung disease (SSC-ILD), a serious fibrotic condition characterized...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant totaling $150,152 to the University of California, Los Angeles (UCLA) Office of Research Administration, effective March 27, 2026, through February 28, 2029. Under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), UCLA will conduct research characterizing migratory cell differentiation in developing zebrafish skin. The project...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Texas Health Science Center at Houston a $623,286 Project Grant on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This five-year award, extending through June 30, 2031, funds research investigating the mechanisms of lung and skin fibrosis in systemic sclerosis (SSC), a disease characterized by dysregulated epithelial cell differentiation and activation that contributes to high morbidity and mortality. The research services delivered under this award focus on elucidating the hypoxia-driven role of NUDT21 (CFIM25) protein in regulating profibrotic mediators through alternative polyadenylation mechanisms in epithelial cells. The project employs preclinical research methodologies utilizing mouse models with epithelial-specific NUDT21 knockout in skin and lung tissues, alongside human tissue analysis, to establish the causal relationship between hypoxia-induced NUDT21 downregulation and fibrosis development. Research outputs will include mechanistic data on gene expression regulation, animal model findings, and peer-reviewed publications advancing understanding of SSC pathogenesis and identifying potential therapeutic targets for treating this serious connective tissue disease.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $623.3k | 6/19/26 |