Project Grant R01AR086434
- This federal Project Grant award for $434,722 from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) provides funding to the University of Pittsburgh to conduct a collaborative multiomic study of pediatric scleroderma. The project aims to molecularly characterize and stratify patients with this rare autoimmune disorder through a multidisciplinary research approach. The 4-year award, which commenced on August 15, 2025, will support the University of...
- This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $2,671,990.00 to the University of Pittsburgh for a collaborative, multiomic approach to molecularly characterize and stratify pediatric scleroderma patients. The 4-year project aims to transform healthcare for military service members, veterans, and the broader public by advancing biomedical research in this area. The award began on Aug 15, 2025 and is...
- This federal Project Grant award of $172,584.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting a 5-year research career development program. The award recipient, The Trustees of Columbia University in the City of New York, will utilize multi-omics analyses to prioritize potentially causal genes associated with systemic sclerosis (SSc), a serious autoimmune...
- This National Institutes of Health (NIH) Arthritis, Musculoskeletal and Skin Diseases Research grant award, provided through the CFDA Program 93.846, is for a K01 Mentored Research Scientist Development Award titled "Deciphering the Regulation of TGF-β3 in Driving Myofibroblast Differentiation in Systemic Sclerosis." The $113,090 award supports research by Dr. Mengqi Huang of the University of Pittsburgh to investigate the epigenetic regulatory networks driving increased expression...
- This Project Grant award of $147,400.00, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the mechanisms by which antigen non-related CD4+ T cells contribute to the pathogenesis of skin fibrosis in systemic sclerosis (scleroderma) and sclerodermoid graft-versus-host disease. The project, conducted by Yale University, will use mouse models to...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $704,424 to support research efforts to identify rare pathogenic variants and their functional consequences in Systemic Lupus Erythematosus (SLE). The key objectives are to: 1) apply whole genome sequencing on 127 SLE multiplex, simplex, and early-onset pediatric cases to define...
- This Project Grant award, totaling $176,148.00 and effective from April 1, 2025 to March 31, 2030, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The funding supports a research project led by Dr. Maxime Kinet at the University of California, San Francisco (UCSF) that aims to elucidate the mechanisms by which PI16-expressing fibroblasts, a...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) provides $173,719.00 to Boston University Medical Campus to conduct research on using Spatial Frequency Domain Imaging (SFDI) as an objective method to quantify and monitor skin changes in patients with Systemic Sclerosis (SSc), a severe autoimmune connective tissue disease. The research aims to prospectively evaluate SFDI's...
- The federal Project Grant award of $649,391 provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting research to enhance healing after injury. The overarching objective is to define the mechanisms that restrain tissue regeneration in order to develop new therapeutics to improve healing of the gut and skin following injury or infection. The 5-year project, which...
- This federal Project Grant award, valued at $1,901,310.00 and provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), supports research under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research project aims to investigate how skin inflammation drives the development of psoriatic arthritis, a condition that affects up to one-third of individuals with psoriasis. The project will use a novel mouse model to study the...
The federal Project Grant award of $504,442.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize molecular endotypes in pediatric scleroderma. The project aims to integrate single-cell and spatial transcriptomics with histological analysis to identify disease subgroups and inform personalized treatment strategies. By leveraging advanced research methods, the University of Pittsburgh researchers seek to enhance patient stratification and develop molecularly-guided therapies to improve clinical outcomes for children with scleroderma. This 5-year project is expected to be completed by August 31, 2030 and represents a key effort to advance precision medicine in this complex fibrotic disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $504.4k | 9/2/25 |