Project Grant K23AR084061
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize hematopoietic stem cell (HSC) impairment in a mouse model of systemic lupus erythematosus (SLE)-like disease. The $216,113 award to New York University School of Medicine will be used to test the hypothesis that SLE-like disease impairs HSC activity, potentially...
- This National Institutes of Health (NIH) Arthritis, Musculoskeletal and Skin Diseases Research grant award, provided through the CFDA Program 93.846, is for a K01 Mentored Research Scientist Development Award titled "Deciphering the Regulation of TGF-β3 in Driving Myofibroblast Differentiation in Systemic Sclerosis." The $113,090 award supports research by Dr. Mengqi Huang of the University of Pittsburgh to investigate the epigenetic regulatory networks driving increased expression...
- This Project Grant award of $147,400.00, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to investigate the mechanisms by which antigen non-related CD4+ T cells contribute to the pathogenesis of skin fibrosis in systemic sclerosis (scleroderma) and sclerodermoid graft-versus-host disease. The project, conducted by Yale University, will use mouse models to...
- The federal Project Grant award of $504,442.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to characterize molecular endotypes in pediatric scleroderma. The project aims to integrate single-cell and spatial transcriptomics with histological analysis to identify disease subgroups and inform personalized treatment strategies. By leveraging...
- This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
- This federal Project Grant award of $129,035 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports a 5-year research training program. The award aims to advance the principal investigator's expertise in centrosome, cytoskeletal, and keratinocyte biology, with a focus on understanding the role of the centrosomal protein CEP43 in maintaining epidermal integrity and its...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $704,424 to support research efforts to identify rare pathogenic variants and their functional consequences in Systemic Lupus Erythematosus (SLE). The key objectives are to: 1) apply whole genome sequencing on 127 SLE multiplex, simplex, and early-onset pediatric cases to define...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $676,841 Project Grant titled "LEVERAGING HUMAN MUSCULOSKELETAL DEVELOPMENT TO IDENTIFY CAUSAL DISEASE VARIANTS" to President and Fellows of Harvard College. The award period runs from August 1, 2025 to July 31, 2030 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The objective of the project is to conduct targeted functional genomic studies...
- The $735,372 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research Program (CFDA 93.846) supports research to identify the key transcription factors and cytokine signals that regulate the expression of inflammatory chemokine receptors on T cells in chronic autoimmune conditions. The goal is to elucidate the dominant pathways controlling coordinated T cell migration to...
- This Project Grant award of $139,895.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the link between inflammatory arthritis and the development of cardiovascular disease. The key objectives are to investigate whether "trained immunity" - the phenomenon where innate immune cells become reprogrammed to respond more efficiently to a...
This federal Project Grant award of $172,584.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting a 5-year research career development program. The award recipient, The Trustees of Columbia University in the City of New York, will utilize multi-omics analyses to prioritize potentially causal genes associated with systemic sclerosis (SSc), a serious autoimmune rheumatic disease. The research aims to leverage population genetics and single-cell sequencing data to generate hypotheses that can guide development of new therapeutic approaches for SSc, which has seen limited treatment advances in recent decades. The award will equip the principal investigator, a rheumatologist, with cross-disciplinary skills in -omics science and precision medicine as they transition to an independent physician-scientist role.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $172.6k | 8/15/25 |